INT157463

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 55
Total Number 59
Disease Relevance 69.05
Pain Relevance 19.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CX3CL1) extracellular region (CX3CL1) plasma membrane (CX3CL1)
cytoplasm (CX3CL1)
Anatomy Link Frequency
plasma 4
heart 4
coronary artery 3
endothelial cells 3
smooth muscle cells 3
CX3CL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 804 100.00 Very High Very High Very High
Pain 54 99.86 Very High Very High Very High
Chronic pancreatitis 63 99.84 Very High Very High Very High
Inflammation 1666 99.52 Very High Very High Very High
fibrosis 30 99.38 Very High Very High Very High
Visceral pain 7 99.00 Very High Very High Very High
Neuritis 35 98.32 Very High Very High Very High
cytokine 341 96.88 Very High Very High Very High
antagonist 56 94.36 High High
Neuropathic pain 7 89.32 High High
Disease Link Frequency Relevance Heat
Cardiovascular Disease 137 99.98 Very High Very High Very High
Atherosclerosis 739 99.92 Very High Very High Very High
Coronary Artery Disease 1845 99.84 Very High Very High Very High
Diabetes Mellitus 1030 99.84 Very High Very High Very High
Diabetes Mellitus-type I 984 99.84 Very High Very High Very High
Pancreatitis 63 99.84 Very High Very High Very High
Hyperlipidemia 862 99.74 Very High Very High Very High
Disease 532 99.72 Very High Very High Very High
INFLAMMATION 1631 99.52 Very High Very High Very High
Fibrosis 44 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, pancreatic fractalkine expression appears to be linked to visceral pain and to the recruitment of inflammatory cells into the pancreatic tissue and nerve fibers, with subsequent pancreatic neuritis.
Gene_expression (expression) of fractalkine in nerve associated with visceral pain, inflammation and neuritis
1) Confidence 0.62 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.39 Pain Relevance 1.30
CX3CR1, but not fractalkine, mRNA was overexpressed in CP.
Gene_expression (overexpressed) of fractalkine associated with chronic pancreatitis
2) Confidence 0.62 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 2.07 Pain Relevance 1.67
Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis.
Gene_expression (expression) of fractalkine in Neural associated with pain, chronic pancreatitis and neuritis
3) Confidence 0.62 Published 2009 Journal Lab. Invest. Section Title Doc Link 19153557 Disease Relevance 1.74 Pain Relevance 1.52
Furthermore, fractalkine and CX3CR1 mRNA overexpressions were associated with enhanced lymphocyte and macrophage infiltration.
Gene_expression (overexpressions) of fractalkine in lymphocyte
4) Confidence 0.62 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.86 Pain Relevance 1.52
Advanced fibrosis was associated with increased fractalkine expression, whereas in vitro fractalkine had no significant impact on collagen-1 and alpha-SMA expressions in hPSCs.
Gene_expression (expression) of fractalkine associated with fibrosis
5) Confidence 0.62 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.63 Pain Relevance 1.47
In contrast, the protein levels of both CX3CR1 and fractalkine were upregulated.
Gene_expression (levels) of fractalkine
6) Confidence 0.48 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 2.04 Pain Relevance 1.70
Fractalkine/CX3CL1 is synthesized by endothelial cells as a type 1 transmembrane protein which is then cleaved by proteolysis, possibly mediated by TNF-?
Gene_expression (synthesized) of CX3CL1 in endothelial cells
7) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.12 Pain Relevance 0.35
Fractalkine/CX3CL1 is synthesized by endothelial cells as a type 1 transmembrane protein which is then cleaved by proteolysis, possibly mediated by TNF-?
Gene_expression (synthesized) of Fractalkine in endothelial cells
8) Confidence 0.38 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.12 Pain Relevance 0.35
In addition to the expression of E-selectin, CCL17, CXCL16, CX3CL1, and increased numbers of integrin ligands [33-35], we show here for the first time a very early production of CS-1 fibronectin by activated endothelial cells in patients with ACD.
Gene_expression (expression) of CX3CL1 in endothelial cells associated with contact dermatitis
9) Confidence 0.36 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.09 Pain Relevance 0
Fractalkine levels have only been rarely determined in patients; however, it has been shown that Alzheimer patients express enhanced fractalkine levels, correlating with the Mini-Mental State Examination (MMSE) score.20 Another study also reported that fractalkine levels are enhanced in Wegener’s granulomatosis.21 In patients with coronary artery disease fractalkine plasma levels were enhanced and then reduced after statin therapy.22 When CX3CR1 genotypes were analyzed in patients with acute coronary syndromes and healthy controls, CX3CR1-I249 heterozygosity was associated with a markedly reduced risk of acute coronary events, independent of established coronary risk factors such as smoking or diabetes.23,24
Gene_expression (express) of fractalkine in plasma associated with acute coronary syndrome, nicotine addiction, diabetes mellitus and cardiovascular disease
10) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.77 Pain Relevance 0.17
Thus, in the present study we investigated the expression of serum fractalkine in patients with coronary heart disease (CHD) and patients with insulin-dependent diabetes following optimized medical treatment after a period of rehabilitation.
Spec (investigated) Gene_expression (expression) of fractalkine in heart associated with coronary artery disease and diabetes mellitus
11) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.43 Pain Relevance 0.19
Fractalkine is a multidomain protein expressed on the surface of a variety of cells, including activated endothelial and smooth muscle cells.11–15 Fractalkine exhibits features which have not been described for other members of the chemokine family, including its exceptionally large size of 95 kDa and the presence of a transmembrane anchor.
Gene_expression (expressed) of Fractalkine in smooth muscle cells associated with chemokine
12) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.11 Pain Relevance 0.27
Serum fractalkine levels in CHD and IDDM patients following rehabilitation did not differ from those in healthy control subjects.
Gene_expression (levels) of fractalkine associated with diabetes mellitus-type i and coronary artery disease
13) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.13 Pain Relevance 0.15
Upregulated fractalkine and CX3CR1 levels were present in the early stage of diabetic kidney disease in rats.28 The aforementioned data suggest that fractalkine and CX3CR1 have an important role in the progression of diabetic nephropathy, functioning as an arrest chemokine in monocyte/macrophage adhesion before migration into the kidney.
Gene_expression (present) of fractalkine in kidney associated with chemokine, adhesions and diabetic nephropathy
14) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.89 Pain Relevance 0.22
Thus, fractalkine levels in both patient groups were below or equal to control levels.


Gene_expression (levels) of fractalkine
15) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.76 Pain Relevance 0.11
Thus, we analyzed the expression of fractalkine in the IDDM and CHD patients who received optimal medical treatment and underwent rehabilitation for four weeks.
Spec (analyzed) Gene_expression (expression) of fractalkine associated with diabetes mellitus-type i and coronary artery disease
16) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.30 Pain Relevance 0.05
Cytokines and chemokines may contribute to regulate atherosclerosis-related pathways in diabetes or its associated diseases.26,27 However, little is known about the expression of fractalkine and its receptor in diabetes, although the mRNA of fractalkine and its receptor were upregulated in diabetic rats in the early stages of diabetic nephropathy.28
Gene_expression (expression) of fractalkine associated with chemokine, diabetes mellitus, atherosclerosis, disease, diabetic nephropathy and cytokine
17) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.44 Pain Relevance 0.12
It is interesting to note that the expression of the majority of the molecules (FGF-2, Fractalkine, GRO, G-CSF, IL-8, IL-1?
Gene_expression (expression) of Fractalkine
18) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2923116 Disease Relevance 0.48 Pain Relevance 0.20
Similarly to other studies we were not able to show any significant correlation between fractalkine levels and other classical risk factors for atherosclerosis, such as lipid metabolism (HDL-C, LDL-C, TC, and TG), age, BMI, or diabetes.22,23 In our study, fractalkine serum levels were not significantly elevated in patients who received CABG surgery within two weeks before attending rehabilitation.
Gene_expression (levels) of fractalkine associated with diabetes mellitus, atherosclerosis, obesity and disorder of lipid metabolism
19) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.88 Pain Relevance 0.26
These data indicate that the fractalkine levels were similar to control values and that acute hyperlipemia did not alter fractalkine levels in patients, whereas it did so in controls.
Gene_expression (levels) of fractalkine associated with hyperlipidemia
20) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.32 Pain Relevance 0.19

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