INT157464

Context Info Confidence 0.68 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.97 Pain Relevance 1.92

cell adhesion (CX3CR1) plasma membrane (CX3CR1) signal transducer activity (CX3CR1)

Anatomy Link Frequency kidney 1 CX3CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 9 98.32 Pain 6 92.00 chemokine 15 90.80 Neuritis 5 90.40 Inflammation 43 83.36 Angina 1 80.04 fibrosis 4 79.04 glial activation 1 60.20 Neuropathic pain 1 59.20 antagonist 1 56.64

Disease Link Frequency Relevance Heat Diabetic Nephropathy 5 99.24 Pancreatitis 9 98.32 Pain 5 92.00 Neuritis 5 90.40 Adhesions 12 89.48 Fibrosis 6 88.24 INFLAMMATION 42 83.36 Hypertrophy 1 81.16 Cv General 3 Under Development 1 80.04 Coronary Artery Disease 45 70.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, the protein levels of both CX3CR1 and fractalkine were upregulated.

Positive_regulation (upregulated) of CX3CR1

1) Confidence 0.68 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 2.03 Pain Relevance 1.70

Upregulated fractalkine and CX3CR1 levels were present in the early stage of diabetic kidney disease in rats.28 The aforementioned data suggest that fractalkine and CX3CR1 have an important role in the progression of diabetic nephropathy, functioning as an arrest chemokine in monocyte/macrophage adhesion before migration into the kidney.

Positive_regulation (Upregulated) of CX3CR1 in kidney associated with chemokine, adhesions and diabetic nephropathy

2) Confidence 0.17 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.88 Pain Relevance 0.21

General Comments

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