INT157465

Context Info Confidence 0.49 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 8.90 Pain Relevance 6.62

cell adhesion (CX3CR1) plasma membrane (CX3CR1) signal transducer activity (CX3CR1)

Anatomy Link Frequency lymphocyte 3 kidney 2 macrophage 1 CX3CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 36 99.84 Neuritis 20 94.60 Pain 24 93.64 fibrosis 16 93.60 chemokine 18 91.60 Inflammation 61 87.32 Angina 1 80.04 Visceral pain 4 74.64 glial activation 4 64.16 Neuropathic pain 4 63.16

Disease Link Frequency Relevance Heat Pancreatitis 36 99.84 Diabetic Nephropathy 5 99.24 Neuritis 20 94.60 Pain 20 93.64 Fibrosis 24 93.60 Adhesions 12 90.28 INFLAMMATION 60 87.32 Hypertrophy 4 85.12 Cv General 3 Under Development 1 80.04 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 4 74.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, fractalkine and CX3CR1 mRNA overexpressions were associated with enhanced lymphocyte and macrophage infiltration.

Positive_regulation (overexpressions) of Gene_expression (overexpressions) of CX3CR1 mRNA in lymphocyte

1) Confidence 0.49 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.85 Pain Relevance 1.51

CX3CR1, but not fractalkine, mRNA was overexpressed in CP.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CX3CR1 associated with chronic pancreatitis

2) Confidence 0.49 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 2.08 Pain Relevance 1.68

In contrast, the protein levels of both CX3CR1 and fractalkine were upregulated.

Positive_regulation (upregulated) of Gene_expression (levels) of CX3CR1

3) Confidence 0.46 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 2.04 Pain Relevance 1.71

Upregulated fractalkine and CX3CR1 levels were present in the early stage of diabetic kidney disease in rats.28 The aforementioned data suggest that fractalkine and CX3CR1 have an important role in the progression of diabetic nephropathy, functioning as an arrest chemokine in monocyte/macrophage adhesion before migration into the kidney.

Positive_regulation (Upregulated) of Gene_expression (present) of CX3CR1 in kidney associated with chemokine, adhesions and diabetic nephropathy

4) Confidence 0.19 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.89 Pain Relevance 0.22

Furthermore, fractalkine and CX3CR1 mRNA overexpressions were associated with enhanced lymphocyte and macrophage infiltration.

Positive_regulation (overexpressions) of in macrophage Gene_expression (overexpressions) of CX3CR1 mRNA in lymphocyte

5) Confidence 0.17 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.85 Pain Relevance 1.51

General Comments

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