INT157466

Context Info Confidence 0.76 First Reported 2005 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 14 Total Number 18 Disease Relevance 20.60 Pain Relevance 10.76

cell adhesion (CX3CR1) plasma membrane (CX3CR1) signal transducer activity (CX3CR1)

Anatomy Link Frequency monocyte 3 plasma 2 leukocytes 2 macrophage 1 lymphocyte 1 CX3CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 260 100.00 Chronic pancreatitis 36 99.84 rheumatoid arthritis 269 99.44 Inflammation 373 96.16 Neuritis 20 94.60 Pain 58 93.64 fibrosis 16 93.60 Arthritis 62 93.04 b2 receptor 16 92.32 Angina 12 90.60

Disease Link Frequency Relevance Heat Atherosclerosis 89 100.00 Acute Coronary Syndrome 4 100.00 Adhesions 84 99.92 Pancreatitis 36 99.84 Arthritis 56 99.68 Rheumatoid Arthritis 278 99.44 Diabetic Nephropathy 20 99.08 Cardiovascular Disease 34 98.26 Diabetes Mellitus 381 98.24 Asthma 7 96.80

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Anatomy

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Speculation

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Disease term

Furthermore, fractalkine and CX3CR1 mRNA overexpressions were associated with enhanced lymphocyte and macrophage infiltration.

Gene_expression (overexpressions) of CX3CR1 mRNA in lymphocyte

1) Confidence 0.76 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.85 Pain Relevance 1.51

CX3CR1, but not fractalkine, mRNA was overexpressed in CP.

Gene_expression (overexpressed) of CX3CR1 associated with chronic pancreatitis

2) Confidence 0.76 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 2.08 Pain Relevance 1.68

In contrast, the protein levels of both CX3CR1 and fractalkine were upregulated.

Gene_expression (levels) of CX3CR1

3) Confidence 0.59 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 2.03 Pain Relevance 1.65

It interacts with the unique receptor CX3CR1 that is expressed on monocytes, natural killer cells, and some T cells.

Gene_expression (expressed) of CX3CR1 in natural killer cells

4) Confidence 0.52 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.58 Pain Relevance 0.31

Soluble fractalkine/CX3CL1 is a potent chemoattractant for CX3CR1+ leukocytes.

Gene_expression (leukocytes) of CX3CR1 in leukocytes

5) Confidence 0.39 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.49 Pain Relevance 0.27

Individual cell populations in PB, BKmig and BKnon were identified according to their surface expression levels of CD34 (Miltenyi), KDR (R&D systems), CXCR4 (BD), CD14 (Miltenyi), CD16 (BD), CX3CR1 (Caltag) by flow cytometry (Fig.

Gene_expression (levels) of CX3CR1

6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.06 Pain Relevance 0.16

Individual cell populations in PB, BKmig and BKnon were identified according to their surface expression levels of CD34 (Miltenyi), KDR (R&D systems), CXCR4 (BD), CD14 (Miltenyi), CD16 (BD), CX3CR1 (Caltag) by flow cytometry (Fig.

Gene_expression (expression) of CX3CR1

7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.06 Pain Relevance 0.16

No significant differences in co-expression of CX3CR1, CXCR4, or KDR were detected by comparing H vs.

Gene_expression (expression) of CX3CR1

8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.69 Pain Relevance 0.13

The fractalkine receptor CX3CR1, previously associated with recruitment of pro-atherosclerotic cells and their retention in the vessel wall [15], was co-expressed on the majority of CD16pos monocyte subtypes and less frequent on CD14hiCD16neg monocytes, with no significant differences between H and T1D (Fig. 1B).

Gene_expression (expressed) of CX3CR1 in monocyte associated with diabetes mellitus and atherosclerosis

9) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 1.09 Pain Relevance 0.05

Most CXC and CC chemokine receptors mentioned above as well as XCR1 and CX3CR1 are expressed in the arthritic synovium [14,17,18].

Gene_expression (expressed) of CX3CR1 in synovium associated with chemokine and arthritis

10) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 1.02 Pain Relevance 0.55

Upregulated fractalkine and CX3CR1 levels were present in the early stage of diabetic kidney disease in rats.28 The aforementioned data suggest that fractalkine and CX3CR1 have an important role in the progression of diabetic nephropathy, functioning as an arrest chemokine in monocyte/macrophage adhesion before migration into the kidney.

Gene_expression (present) of CX3CR1 in kidney associated with chemokine, adhesions and diabetic nephropathy

11) Confidence 0.29 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.83 Pain Relevance 0.22

In this way, membrane-bound fractalkine contributes to the adhesion of CX3CR1-expressing leukocytes.

Gene_expression (expressing) of CX3CR1 in leukocytes associated with adhesions

12) Confidence 0.29 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.69 Pain Relevance 0.38

Furthermore, fractalkine and CX3CR1 mRNA overexpressions were associated with enhanced lymphocyte and macrophage infiltration.

Gene_expression (overexpressions) of CX3CR1 mRNA in macrophage

13) Confidence 0.26 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.85 Pain Relevance 1.51

These were CCR1, CCR2a, CCR5, CCR7, CCR9, CX3CR1, CXCR1, CXCR2, CXCR4, CXCR5, CXCR6 (STRL33) and Bob (Table 3).

Gene_expression (These) of CX3CR1

14) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.02 Pain Relevance 0.80

Fractalkine levels have only been rarely determined in patients; however, it has been shown that Alzheimer patients express enhanced fractalkine levels, correlating with the Mini-Mental State Examination (MMSE) score.20 Another study also reported that fractalkine levels are enhanced in Wegener’s granulomatosis.21 In patients with coronary artery disease fractalkine plasma levels were enhanced and then reduced after statin therapy.22 When CX3CR1 genotypes were analyzed in patients with acute coronary syndromes and healthy controls, CX3CR1-I249 heterozygosity was associated with a markedly reduced risk of acute coronary events, independent of established coronary risk factors such as smoking or diabetes.23,24

Gene_expression (syndromes) of CX3CR1 in plasma associated with acute coronary syndrome, nicotine addiction, diabetes mellitus and cardiovascular disease

15) Confidence 0.25 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.79 Pain Relevance 0.11

Fractalkine levels have only been rarely determined in patients; however, it has been shown that Alzheimer patients express enhanced fractalkine levels, correlating with the Mini-Mental State Examination (MMSE) score.20 Another study also reported that fractalkine levels are enhanced in Wegener’s granulomatosis.21 In patients with coronary artery disease fractalkine plasma levels were enhanced and then reduced after statin therapy.22 When CX3CR1 genotypes were analyzed in patients with acute coronary syndromes and healthy controls, CX3CR1-I249 heterozygosity was associated with a markedly reduced risk of acute coronary events, independent of established coronary risk factors such as smoking or diabetes.23,24

Spec (analyzed) Gene_expression (genotypes) of CX3CR1 in plasma associated with acute coronary syndrome, nicotine addiction, diabetes mellitus and cardiovascular disease

16) Confidence 0.22 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 0.77 Pain Relevance 0.11

express only select types of the numerous chemokine receptors (for example, CCR1, 2, 5, 7, and 8 as well as CX3CR1), representing a partially specific basis for prominent trafficking of monocyte/M?

Gene_expression (express) of CX3CR1 in monocyte associated with chemokine

17) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.98 Pain Relevance 0.86

It interacts with the unique receptor CX3CR1 that is expressed on monocytes, natural killer cells, and some T cells.

Gene_expression (expressed) of CX3CR1 in monocytes

18) Confidence 0.18 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.58 Pain Relevance 0.31

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