INT157500

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.21
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DNMT3B) nucleus (DNMT3B) DNA binding (DNMT3B)
cytoplasm (DNMT3B)
Anatomy Link Frequency
arm 1
leg 1
urine 1
DNMT3B (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 134 99.44 Very High Very High Very High
Pain 24 99.30 Very High Very High Very High
Lasting pain 2 94.72 High High
palliative 5 50.00 Quite Low
Osteoarthritis 7 36.68 Quite Low
cva 1 21.84 Low Low
Sciatica 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
spinal stenosis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 11 99.60 Very High Very High Very High
Low Back Pain 138 99.44 Very High Very High Very High
Cognitive Disorder 8 95.68 Very High Very High Very High
Pain 24 94.72 High High
Cancer 62 92.20 High High
Deafness 3 86.04 High High
Overactive Bladder 2 67.84 Quite High
Chronic Disease 5 49.32 Quite Low
Frailty 10 39.20 Quite Low
Hemorrhage 1 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Survival time, and BIS measures of basal metabolic rate and 11 body composition parameters (extracellular fluid [ECF], intracellular fluid [ICF], ratio of ECF to ICF, fluid in trunk and each arm and leg, protein mass, mineral mass, and percent body fat) were recorded for 84 oncology patients.
Localization (ratio) of ICF in arm
1) Confidence 0.73 Published 2009 Journal J Palliat Med Section Body Doc Link 19663711 Disease Relevance 0.09 Pain Relevance 0
OBJECTIVE: To introduce the International Classification of Functioning, Disability and Health (ICF) as conceptual model and classification and the ICF Core Sets as a way to specify functioning for a specific health condition such as Low Back Pain, and to illustrate the application of the ICF and ICF Core Sets in the context of clinical practice, the planning and reporting of studies and the comparison of health status measures.
Localization (application) of ICF associated with low back pain and pain
2) Confidence 0.71 Published 2009 Journal Clin J Pain Section Abstract Doc Link 19158543 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To introduce the International Classification of Functioning, Disability and Health (ICF) as conceptual model and classification and the ICF Core Sets as a way to specify functioning for a specific health condition such as Low Back Pain, and to illustrate the application of the ICF and ICF Core Sets in the context of clinical practice, the planning and reporting of studies and the comparison of health status measures.
Localization (application) of ICF associated with low back pain and pain
3) Confidence 0.71 Published 2009 Journal Clin J Pain Section Abstract Doc Link 19158543 Disease Relevance 0.17 Pain Relevance 0.17
The International Classification of Functioning, Disability and Health (ICF) released by the World Health Organization [10]) provides a unified framework for evaluating health and health-related states of populations and also provides a common language for communication among health care professionals [11,12].
Localization (released) of ICF
4) Confidence 0.63 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2614963 Disease Relevance 0 Pain Relevance 0
Reliability of the ICF qualifiers
Localization (Reliability) of ICF
5) Confidence 0.61 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1199614 Disease Relevance 0.19 Pain Relevance 0
Immeasurability of the ICF items
Localization (Immeasurability) of ICF
6) Confidence 0.61 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1199614 Disease Relevance 0 Pain Relevance 0
As shown in Figures 2 and 3, the low weighted kappa value of chapters 4, 5 and 8 of the BF domain, and chapters 8 and 9 of the AP domain contribute to the overall low reliability of the ICF.
Localization (reliability) of ICF
7) Confidence 0.61 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1199614 Disease Relevance 0.06 Pain Relevance 0
All these considerations also apply to the validation of this ICF Core Set for LBP.
Localization (validation) of ICF associated with backache
8) Confidence 0.36 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.34 Pain Relevance 0.34
These enzymes are mainly responsible for introducing cytosine methylation at previously unmethylated CpG sites by at least three possible means: first, DNMT3 enzymes themselves might recognize DNA or chromatin via specific domains; second, DNMT3a and DNMT3b might be recruited through protein-protein interactions with transcriptional repressors or other factors, and third, the RNA-mediated interference (RNAi) system might target de novo methylation to specific DNA sequences [18].
Localization (recruited) of DNMT3b
9) Confidence 0.34 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0 Pain Relevance 0
These aspects should therefore be taken into consideration in a revised Comprehensive ICF Core Set.
Localization (revised) of ICF
10) Confidence 0.32 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.97 Pain Relevance 0.69
METHODS: Survival time, and BIS measures of basal metabolic rate and 11 body composition parameters (extracellular fluid [ECF], intracellular fluid [ICF], ratio of ECF to ICF, fluid in trunk and each arm and leg, protein mass, mineral mass, and percent body fat) were recorded for 84 oncology patients.
Localization (ratio) of ICF in leg
11) Confidence 0.25 Published 2009 Journal J Palliat Med Section Body Doc Link 19663711 Disease Relevance 0.09 Pain Relevance 0
In the present study, the predictions mainly concern six individual parameters characterizing the hydromineral parameters and homeostatic responses: The ECF [Na+] and volume, the ICF volume, the AVP secretion and the cumulative water intake and urine excretion.
Localization (secretion) of ICF in urine
12) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0.13 Pain Relevance 0

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