INT157506

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.69
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ly96)
Anatomy Link Frequency
bowel 3
epithelial cells 2
MD2 1
HeLa 1
C3A 1
Ly96 (Mus musculus)
Pain Link Frequency Relevance Heat
spastic colon 24 97.96 Very High Very High Very High
tolerance 84 80.80 Quite High
Inflammatory response 13 69.52 Quite High
agonist 8 55.04 Quite High
Inflammation 135 50.00 Quite Low
ketamine 4 19.44 Low Low
cytokine 26 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 43 98.16 Very High Very High Very High
Functional Bowel Disorder 12 97.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 96.92 Very High Very High Very High
Targeted Disruption 8 87.28 High High
INFLAMMATION 133 69.52 Quite High
Cirrhosis 14 50.00 Quite Low
Attention Deficit Hyperactivity Disorder 2 26.60 Quite Low
Sepsis 72 5.00 Very Low Very Low Very Low
Obesity 56 5.00 Very Low Very Low Very Low
Disease 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Confluent monolayers of C3A cells were treated with PA (100 mM) or PA + anti-TLR-4/MD2 blocking antibody (2 ?
Gene_expression (/) of MD2 in C3A
1) Confidence 0.30 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.25 Pain Relevance 0
Confluent monolayers of C3A cells were treated with PA (100 mM) or PA + anti-TLR-4/MD2 blocking antibody (2 ?
Gene_expression (treated) of MD2 in MD2
2) Confidence 0.30 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.25 Pain Relevance 0
OBJECTIVE: To study the expression of TLR4, myeloid differential protein 2 (MD-2), and nuclear factor (NF)-kappa B in the colonic mucosa with irritable bowel syndrome (IBS) in patients and to explore the role of TLR4 in the pathogenesis of IBS and TLR4 signal transduction pathway.
Gene_expression (expression) of MD-2 in bowel associated with spastic colon
3) Confidence 0.14 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 19159572 Disease Relevance 0.17 Pain Relevance 0.36
OBJECTIVE: To study the expression of TLR4, myeloid differential protein 2 (MD-2), and nuclear factor (NF)-kappa B in the colonic mucosa with irritable bowel syndrome (IBS) in patients and to explore the role of TLR4 in the pathogenesis of IBS and TLR4 signal transduction pathway.
Gene_expression (expression) of myeloid differential protein 2 in bowel associated with spastic colon
4) Confidence 0.14 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 19159572 Disease Relevance 0.17 Pain Relevance 0.36
The low and negative expression of MD-2 may contribute to the tolerance with the intestinal commensal bacteria.


Gene_expression (expression) of MD-2
5) Confidence 0.14 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19159572 Disease Relevance 0 Pain Relevance 0
MD-2 expression was not seen in the intestinal epithelial cells (IECs) of 10 healthy controls and was lowly expressed in the sigmoid mucosa of 2 of the 12 healthy controls; and was lowly expressed in 4 of the IBS patients and not expressed in 26 of the 30 IBS patients.
Gene_expression (expression) of MD-2 in epithelial cells
6) Confidence 0.14 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19159572 Disease Relevance 0 Pain Relevance 0
METHODS: Immunohistochemistry was used to detect the expression of TLR4, MD-2, and NF-kappaB in the colon mucosa specimens of 30 patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and 12 healthy volunteers obtained by colonoscopy.
Gene_expression (expression) of MD-2 in bowel
7) Confidence 0.14 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19159572 Disease Relevance 0 Pain Relevance 0
MD-2 expression was not seen in the intestinal epithelial cells (IECs) of 10 healthy controls and was lowly expressed in the sigmoid mucosa of 2 of the 12 healthy controls; and was lowly expressed in 4 of the IBS patients and not expressed in 26 of the 30 IBS patients.
Gene_expression (expressed) of MD-2 in epithelial cells
8) Confidence 0.11 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19159572 Disease Relevance 0 Pain Relevance 0
Subsequent transfer from CD14 to an additional accessory molecule MD-2 then allows TLR4-mediated LPS recognition [57].
Gene_expression (transfer) of MD-2
9) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.07 Pain Relevance 0.03
The MAT4 cell line that stably expresses human TLR4 and MD-2 (a kind gift from Liwu Li, Virginia Tech University, Blacksburg, VA) was maintained in DMEM supplemented as described for HEK293T cells.
Gene_expression (expresses) of MD-2
10) Confidence 0.02 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.14 Pain Relevance 0.06
As an alternate approach, we established an experimental system utilizing a readily transfectable derivative of the HeLa cell line that stably expresses TLR4 and MD-2 (MAT4).
Gene_expression (expresses) of MD-2 in HeLa
11) Confidence 0.02 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.04

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