INT157514

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (COX18) mitochondrion (COX18)
Anatomy Link Frequency
chondrocyte 2
COX18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 64.40 Quite High
Osteoarthritis 44 37.68 Quite Low
COX2 3 25.00 Low Low
Inflammation 17 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
licofelone 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 6 96.72 Very High Very High Very High
Esophageal Cancer 2 75.00 Quite High
Skin Cancer 1 74.64 Quite High
Cancer 3 67.96 Quite High
INFLAMMATION 23 63.84 Quite High
Osteoarthritis 48 50.00 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.
Negative_regulation (decreased) of Transcription (levels) of COX-2 protein
1) Confidence 0.12 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.82 Pain Relevance 0.13
As described in our previous report [20], COX-2 protein and mRNA expression decreased gradually after 8 hours of chondrocyte incubation with single addition of 10 ?
Negative_regulation (decreased) of Transcription (expression) of COX-2 protein in chondrocyte
2) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0

General Comments

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