INT157522

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM5, OPRM1) signal transducer activity (GRM5, OPRM1) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) cytoplasm (GRM5)
GRM5 (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 11 100.00 Very High Very High Very High
agonist 3 91.04 High High
antagonist 2 86.44 High High
Glutamate receptor 3 75.00 Quite High
Enkephalin 1 67.88 Quite High
tolerance 1 55.28 Quite High
analgesia 1 54.72 Quite High
Opioid 1 54.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a mechanistic basis for the observed effects we suggested an interaction/heterodimerization of MOR and mGluR5, which is supported by the DAMGO-induced co-internalization of MOR and mGluR5 and by the increase of MPEP binding sites (Bmax) and a change of the binding affinity (K(D)) of mGluR5 receptors after the co-expression of MOR.
mGluR5 Regulation (change) of Gene_expression (co-expression) of MOR associated with opioid receptor
1) Confidence 0.28 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.97

General Comments

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