INT157529

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM5) cytoplasm (GRM5) signal transducer activity (GRM5)
Anatomy Link Frequency
odontoblasts 1
embryonic kidney 1
GRM5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 8 100.00 Very High Very High Very High
opioid receptor 22 99.90 Very High Very High Very High
Thermal hyperalgesia 2 99.82 Very High Very High Very High
IPN 2 99.32 Very High Very High Very High
Enkephalin 2 96.08 Very High Very High Very High
tolerance 2 91.40 High High
analgesia 2 90.84 High High
Opioid 2 90.44 High High
unmyelinated 1 88.68 High High
agonist 6 84.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 99.82 Very High Very High Very High
Inflammatory Pain 2 99.32 Very High Very High Very High
Nociception 2 96.64 Very High Very High Very High
INFLAMMATION 1 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support the possibility that the nerve fibers in the dental pulp mediate inflammatory pain and thermal hyperalgesia through coactivation of mGluR5 and TRPV1 and also suggest a possible role for odontoblasts in the transduction of nociceptive signals via mGluR5-mediated mechanism.
Positive_regulation (coactivation) of mGluR5 in odontoblasts associated with nociception, thermal hyperalgesia and ipn
1) Confidence 0.48 Published 2009 Journal J Endod Section Abstract Doc Link 19410084 Disease Relevance 0.59 Pain Relevance 0.50
Therefore, we studied the functional coupling and desensitization of the micro-opioid receptor (MOR) in human embryonic kidney (HEK) 293 cells which co-express metabotropic glutamate receptor 5 (mGluR5).
Positive_regulation (metabotropic) of mGluR5 in embryonic kidney associated with glutamate receptor and opioid receptor
2) Confidence 0.48 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.84
In addition, co-immunoprecipitation experiments revealed evidence for an interaction between MOR and mGluR5 which is facilitated by MPEP treatment.
Positive_regulation (facilitated) of mGluR5 associated with opioid receptor
3) Confidence 0.45 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.72

General Comments

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