INT15753

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Context Info
Confidence 0.37
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.04
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
vagus nerves 2
Ema (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 15 99.76 Very High Very High Very High
qutenza 6 99.54 Very High Very High Very High
Bile 2 63.76 Quite High
abdominal pain 1 50.68 Quite High
backache 4 49.00 Quite Low
Spinal cord 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chordoma 18 99.84 Very High Very High Very High
Pneumothorax 9 99.66 Very High Very High Very High
Breast Cancer 9 99.10 Very High Very High Very High
Ependymoma 74 98.72 Very High Very High Very High
Aggression 2 95.52 Very High Very High Very High
Recurrence 4 93.60 High High
Cancer 33 93.48 High High
Carcinoma 29 92.96 High High
Infarction 1 89.44 High High
Adenocarcinoma 1 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In three dogs, intravenous infusion of a constant incrementally increasing dose of capsaicin, a C-fiber stimulant, decreased EMA in proportion to the dose delivered.
Negative_regulation (decreased) of EMA associated with c fibre and qutenza
1) Confidence 0.37 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1761476 Disease Relevance 0.24 Pain Relevance 0.50
When myelinated fibers were blocked selectively by cooling the vagus nerves to 7 degrees C, EMA decreased to 40% of control (EMA at 39 degrees C).
Negative_regulation (decreased) of EMA in vagus nerves
2) Confidence 0.37 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1761476 Disease Relevance 0.25 Pain Relevance 0.23
On rewarming the vagus nerves to 39 degrees C, we then induced a pneumothorax (27 ml/kg) that eliminated the EMA in all the dogs studied.
Negative_regulation (eliminated) of EMA in vagus nerves associated with pneumothorax
3) Confidence 0.37 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1761476 Disease Relevance 0.28 Pain Relevance 0.36
Both our cases were positive for CAM5.2, AE1AE3, EMA and CK7 but negative for CK20.
Negative_regulation (positive) of EMA
4) Confidence 0.05 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 1.37 Pain Relevance 0
MPE with clear cell changes and positive staining for S-100 protein, keratins and EMA can be misdiagnosed as chordoma, the latter being positive for Cytokeratin markers and S-100 protein but negative for GFAP.
Negative_regulation (misdiagnosed) of EMA associated with ependymoma and chordoma
5) Confidence 0.05 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 1.71 Pain Relevance 0
Immuno-histochemistry indicated a primary breast tumour as the cells were strongly positive for ER, positive for CK19 and EMA and negative for TTF1, CK20, WT1, CK7, Ca19.9 and Ca125.
Negative_regulation (positive) of EMA associated with breast cancer
6) Confidence 0.04 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2694193 Disease Relevance 1.19 Pain Relevance 0.08

General Comments

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