INT157540

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.55
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SP1, YY1) DNA binding (SP1, YY1) nucleus (SP1, YY1)
cell differentiation (YY1) cytoplasm (SP1) chromosome organization (YY1)
Anatomy Link Frequency
lymphocytes 3
SP1 (Homo sapiens)
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 32 99.02 Very High Very High Very High
Morphine 8 89.96 High High
addiction 4 47.20 Quite Low
Disease Link Frequency Relevance Heat
Immunodeficiency 12 93.76 High High
Syndrome 4 92.88 High High
Infection 20 91.92 High High
Repression 8 89.12 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Very Low Very Low Very Low
Morphine Dependence 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of methylation-specific PCR showed that two of 14 CpG islands adjacent to the Sp1 and YY1 elements in the promoter region were methylated, which together with reduced Sp1, contributed to the failure of interaction of Sp1 with YY1 and their binding to the elements, as determined by coimmunoprecipitation, chromatin immunoprecipitation-real-time PCR, and EMSAs.
Sp1 Binding (interaction) of YY1
1) Confidence 0.41 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.75 Pain Relevance 0.35
Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.
Sp1 Binding (interaction) of Ying Yang 1 in lymphocytes associated with mu opioid receptor
2) Confidence 0.30 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.60 Pain Relevance 0.35
Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.
Sp1 Binding (interaction) of YY1 in lymphocytes associated with mu opioid receptor
3) Confidence 0.30 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.60 Pain Relevance 0.35
Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.
specificity protein 1 Binding (interaction) of Ying Yang 1 in lymphocytes associated with mu opioid receptor
4) Confidence 0.30 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.60 Pain Relevance 0.35

General Comments

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