INT157553

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.47
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion organization (Nrf1) nucleus (Nrf1) DNA binding (Nrf1)
molecular_function (Nrf1) cytoplasm (Nrf1)
Anatomy Link Frequency
respiratory 2
neurons 1
Nrf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.12 Very High Very High Very High
Glutamate receptor 2 81.16 Quite High
Glutamate 8 58.40 Quite High
COX2 2 25.00 Low Low
drug abuse 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 60 84.72 Quite High
Lifespan 32 68.24 Quite High
Parkinson's Disease 40 33.84 Quite Low
Diabetes Mellitus 12 28.76 Quite Low
Metabolic Syndrome 8 26.84 Quite Low
Hyperinsulinism 8 24.16 Low Low
Insulin Resistance 12 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Anaemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Silencing of NRF-1 with small interference RNA prevented the depolarization-stimulated up-regulation of Gria2 and COX, and over-expression of NRF-1 rescued neurons from tetrodotoxin-induced down-regulation of Gria2 and COX transcripts.
Gene_expression (over-expression) of NRF-1 in neurons associated with tetrodotoxin
1) Confidence 0.28 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.18
, NRF1, and TFAM were all expressed at higher levels in endurance-trained individuals; however, a key finding is that significant effects of age were evident for PGC-1?
Gene_expression (expressed) of NRF1
2) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2570389 Disease Relevance 0.07 Pain Relevance 0
and TFAM protein content was significantly lower in OY than in YT subjects (P < 0.0001); however, NRF-1 expression was similar in YT and OT subjects.


Gene_expression (expression) of NRF-1
3) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2570389 Disease Relevance 0 Pain Relevance 0.03
To examine molecular and cellular mechanisms responsible for group differences in mitochondrial function, citrate synthase (CS) activity, mtDNA, large-scale protein expression using mass spectrometry, and expression of key mitochondrial transcription factors, including nuclear respiratory factor-1 (NRF-1), mitochondrial transcription factor A (TFAM), and their coregulator, peroxisomal proliferator–activated receptor ?
Gene_expression (expression) of NRF-1 in respiratory
4) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2570389 Disease Relevance 0.20 Pain Relevance 0
To examine molecular and cellular mechanisms responsible for group differences in mitochondrial function, citrate synthase (CS) activity, mtDNA, large-scale protein expression using mass spectrometry, and expression of key mitochondrial transcription factors, including nuclear respiratory factor-1 (NRF-1), mitochondrial transcription factor A (TFAM), and their coregulator, peroxisomal proliferator–activated receptor ?
Gene_expression (expression) of NRF-1 in respiratory
5) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2570389 Disease Relevance 0.20 Pain Relevance 0

General Comments

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