INT157555

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
neurons 2
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.98 Very High Very High Very High
nMDA receptor 11 99.80 Very High Very High Very High
long-term potentiation 83 98.16 Very High Very High Very High
Anterior cingulate cortex 78 89.92 High High
Glutamate receptor 2 78.80 Quite High
Pyramidal cell 5 74.64 Quite High
Hippocampus 4 65.92 Quite High
COX2 2 25.00 Low Low
amygdala 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 46 98.24 Very High Very High Very High
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Silencing of NRF-1 with small interference RNA prevented the depolarization-stimulated up-regulation of Gria2 and COX, and over-expression of NRF-1 rescued neurons from tetrodotoxin-induced down-regulation of Gria2 and COX transcripts.
Positive_regulation (induced) of Regulation (regulation) of Gria2 in neurons associated with tetrodotoxin
1) Confidence 0.28 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.18
On the other hand, these inhibitors did not cause any effects on AMPA and NMDA receptor-mediated EPSCs in CaMKIV transgenic mice (Fig. 3 and 4), suggesting that the inhibition of synaptic potentiation by protein synthesis inhibitors was not due to a functional modification of AMPA and NMDA receptors.
Neg (not) Positive_regulation (cause) of Neg (not) Regulation (effects) of AMPA associated with targeted disruption and nmda receptor
2) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.26 Pain Relevance 0.64

General Comments

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