INT15756

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2011
Negated 0
Speculated 8
Reported most in Abstract
Documents 29
Total Number 37
Disease Relevance 16.58
Pain Relevance 12.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
hippocampus 8
striatum 5
fibroblasts 4
microglia 4
neurons 4
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 57 99.98 Very High Very High Very High
Kinase C 14 99.90 Very High Very High Very High
rheumatoid arthritis 106 99.68 Very High Very High Very High
Nerve growth factor 3 99.64 Very High Very High Very High
Inflammatory response 11 99.62 Very High Very High Very High
Paracetamol 39 99.50 Very High Very High Very High
Hippocampus 31 99.20 Very High Very High Very High
cerebral cortex 4 99.16 Very High Very High Very High
local anesthetic 2 99.12 Very High Very High Very High
anesthesia 11 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 131 100.00 Very High Very High Very High
Convulsion 29 99.98 Very High Very High Very High
Necrosis 24 99.96 Very High Very High Very High
Targeted Disruption 89 99.78 Very High Very High Very High
Aids-related Complex 9 99.76 Very High Very High Very High
Rheumatoid Arthritis 147 99.68 Very High Very High Very High
INFLAMMATION 192 99.44 Very High Very High Very High
Cancer 175 99.30 Very High Very High Very High
Congenital Anomalies 5 98.96 Very High Very High Very High
Coronary Heart Disease 32 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When endotoxin was administered to mice in order to elicit a hepatic inflammatory response without necrosis, increases in c-jun expression occurred without accompanying changes in AP-1 activity, indicating a different mechanism of action.
Positive_regulation (increases) of Gene_expression (expression) of c-jun associated with necrosis and inflammatory response
1) Confidence 0.69 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.59 Pain Relevance 0.57
This association may have induced the expression of several cytokines and immediate early genes in dorsal root ganglion and spinal cord neurons via the TNF signaling pathway.
Spec (may) Positive_regulation (induced) of Gene_expression (expression) of immediate early in spinal cord neurons
2) Confidence 0.67 Published 2004 Journal Spine Section Body Doc Link 15131433 Disease Relevance 0.05 Pain Relevance 0
Expression of Egr1, as well as other immediate early genes, is up-regulated in response to a number of noxious stimuli.
Positive_regulation (up) of Gene_expression (Expression) of immediate early
3) Confidence 0.67 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 0.55 Pain Relevance 0.29
Spinal anesthesia by local anesthetics stimulates the enzyme protein kinase C and induces the expression of an immediate early oncogene, c-Fos.
Positive_regulation (induces) of Gene_expression (expression) of immediate early in Spinal associated with kinase c, anesthesia and local anesthetic
4) Confidence 0.67 Published 1996 Journal Anesth. Analg. Section Title Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.92
and other cytokines induce expression of c-fos and the c-jun oncogene [22-25], we deduced that abnormal expression of c-Fos can be observed in VMC.
Positive_regulation (induce) of Gene_expression (expression) of c-jun associated with coronary heart disease and cytokine
5) Confidence 0.64 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 0.63 Pain Relevance 0.58
In rats chronically infused into the 4th ventricle for 28 days with LPS (via osmotic minipump), there was a region-selective microglia activation, impaired hippocampal-depen-dent memory and altered behaviorally-induced expression of the immediate early gene Arc [234].
Positive_regulation (induced) of Gene_expression (expression) of immediate early in microglia associated with aids-related complex
6) Confidence 0.49 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.77 Pain Relevance 0.15
UVB significantly increased AP-1 activity in Cox-2(-/-) fibroblasts transfected with an AP-1 luciferase reporter gene, and this increase was blocked by NS-389 or piroxicam.
Positive_regulation (transfected) of Gene_expression (transfected) of AP-1 in fibroblasts
7) Confidence 0.48 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12433932 Disease Relevance 0.15 Pain Relevance 0.19
UVB significantly increased AP-1 activity in Cox-2(-/-) fibroblasts transfected with an AP-1 luciferase reporter gene, and this increase was blocked by NS-389 or piroxicam.
Positive_regulation (increased) of Gene_expression (transfected) of AP-1 in fibroblasts
8) Confidence 0.48 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12433932 Disease Relevance 0.16 Pain Relevance 0.20
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Positive_regulation (induced) of Gene_expression (expression) of AP-1 in hippocampus associated with hippocampus
9) Confidence 0.46 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Spec (examined) Positive_regulation (increase) of Gene_expression (expression) of Jun in hippocampus associated with hippocampus
10) Confidence 0.46 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Spec (examined) Positive_regulation (increase) of Gene_expression (expression) of AP-1 in hippocampus associated with hippocampus
11) Confidence 0.46 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Positive_regulation (induced) of Gene_expression (expression) of Jun in hippocampus associated with hippocampus
12) Confidence 0.46 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
Expression of Egr1, as well as other immediate early genes, is up-regulated in response to a number of noxious stimuli.
Positive_regulation (-) of Gene_expression (Expression) of immediate early
13) Confidence 0.45 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 0.55 Pain Relevance 0.29
Expression of Egr1, as well as other immediate early genes, is up-regulated in response to a number of noxious stimuli.
Positive_regulation (regulated) of Gene_expression (Expression) of immediate early
14) Confidence 0.45 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 0.56 Pain Relevance 0.29
The priming phase is characterized by the expression of immediate early genes which causes secondary activation of multiple genes and plays an important role in the initiation of hepatic regeneration.
Positive_regulation (causes) of Gene_expression (expression) of immediate early
15) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.79 Pain Relevance 0.11
In WT mice, acetaminophen caused a time-dependent increase in activator protein-1 nuclear binding activity and in c-Jun expression.
Positive_regulation (increase) of Gene_expression (expression) of c-Jun associated with paracetamol
16) Confidence 0.42 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12842828 Disease Relevance 0.53 Pain Relevance 0.52
In this study, expression of c-fos, c-jun and junB immediate-early genes were followed in mouse brain after irradiation.
Positive_regulation (followed) of Gene_expression (expression) of c-jun in brain
17) Confidence 0.40 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332719 Disease Relevance 0.10 Pain Relevance 0.11
Messenger RNA levels were highest at 25 min following infusion of N-methyl-DL-aspartate. c-jun messenger RNA levels remained elevated for over 2 h; however, c-fos, junB and, NGFI-A messenger RNA levels had returned to control levels by this time.
Positive_regulation (elevated) of Gene_expression (levels) of c-jun
18) Confidence 0.37 Published 1993 Journal Neuroscience Section Abstract Doc Link 8255428 Disease Relevance 0.09 Pain Relevance 0.26
Furthermore, APAP treatment significantly upregulated jun oncogene (c-Jun) gene expression, which was confirmed by Western blotting for both the phosphorylated and the nonphosphorylated forms of c-Jun protein.
Positive_regulation (confirmed) of Gene_expression (expression) of c-Jun associated with paracetamol
19) Confidence 0.32 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.35 Pain Relevance 1.02
Furthermore, APAP treatment significantly upregulated jun oncogene (c-Jun) gene expression, which was confirmed by Western blotting for both the phosphorylated and the nonphosphorylated forms of c-Jun protein.
Positive_regulation (upregulated) of Gene_expression (expression) of c-Jun associated with paracetamol
20) Confidence 0.32 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.35 Pain Relevance 1.02

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