INT15757

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 2.47
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (JUND)
Anatomy Link Frequency
sciatic nerve 1
spinal cord 1
MCF-7 1
dorsal horn 1
JUND (Homo sapiens)
Pain Link Frequency Relevance Heat
c fibre 12 99.76 Very High Very High Very High
Kinase C 2 99.48 Very High Very High Very High
Sciatic nerve 16 99.38 Very High Very High Very High
opioid receptor 6 99.24 Very High Very High Very High
Dorsal horn 16 98.64 Very High Very High Very High
Spinal cord 4 98.24 Very High Very High Very High
dexamethasone 2 94.44 High High
cocaine 1 84.04 Quite High
Arthritis 1 83.44 Quite High
Inflammation 17 82.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 409 99.20 Very High Very High Very High
Repression 15 99.12 Very High Very High Very High
Breast Cancer 2 92.88 High High
Fibrosarcoma 2 87.00 High High
Neuroblastoma 1 84.40 Quite High
Arthritis 2 83.44 Quite High
INFLAMMATION 17 82.72 Quite High
Arthralgia 1 82.04 Quite High
Occupational Lung Diseases 5 80.96 Quite High
Prostate Cancer 1 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genomic expression profile with vitamin D indicated differential expression of gene targets such as c-JUN, JUNB, JUND, FREAC-1/FoxF1, ZNF-44/KOX7, plectin, filamin, and keratin-13, involved in antiproliferative, differentiation pathways.
Gene_expression (expression) of JUND
1) Confidence 0.75 Published 2006 Journal Curr Cancer Drug Targets Section Abstract Doc Link 17168675 Disease Relevance 0.29 Pain Relevance 0.06
JNK increases the expression of JunD, and JunD acts with NF-?
Gene_expression (expression) of JunD
2) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.27 Pain Relevance 0
However expression of activator protein-1 (AP-1), another important transcription factor of MMPs, was not affected by SGlc treatment.
Gene_expression (expression) of activator protein-1
3) Confidence 0.34 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.47 Pain Relevance 0.22
Expression of Cox-2, MDR1/Pgp170, Protein Kinase C (PKC), and Activator Protein 1 (AP1) were investigated in a series of increasingly resistant human MCF-7 breast cancer cells compared to wild type using immunohistochemistry, Western blots, Northern blots, RT-PCR, and Southern blots.
Spec (investigated) Gene_expression (Expression) of Activator Protein 1 in MCF-7
4) Confidence 0.32 Published 2001 Journal Anticancer Res. Section Body Doc Link 11501838 Disease Relevance 0.09 Pain Relevance 0
This indicates that signaling pathways involving protein kinase C and activator protein 1 (AP-1) transcription factors are important for the specific expression pattern of the mu-opioid receptor gene.
Gene_expression (expression) of AP-1 associated with kinase c and opioid receptor
5) Confidence 0.28 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11901219 Disease Relevance 0.08 Pain Relevance 0.62
In addition, GADD45A expression may be regulated by AP-1 complexes containing JunD [66].
Gene_expression (containing) of JunD
6) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.29 Pain Relevance 0
This is in contrast to other studies carried out in different cells, which have shown GR-mediated AP-1 and NF-?
Gene_expression (is) of AP-1
7) Confidence 0.17 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.63 Pain Relevance 0.11
JNK increases the expression of JunD, and JunD acts with NF-?
Gene_expression (expression) of JunD
8) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.28 Pain Relevance 0
Expression of JUN D was increased only after 4 hours.
Gene_expression (Expression) of JUN D
9) Confidence 0.11 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1761754 Disease Relevance 0 Pain Relevance 0.50
One hour after electrical stimulation of the sciatic nerve at A delta/C-fiber intensity, expression of all proteins except JUN D reached its maximum.
Gene_expression (expression) of JUN D in sciatic nerve associated with c fibre and sciatic nerve
10) Confidence 0.11 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1761754 Disease Relevance 0 Pain Relevance 0.49
We present the first comparative investigation of the basal and transsynaptically induced expression of c-JUN, JUN B, JUN D, c-FOS, FOS B, and KROX-24 proteins in the spinal cord, using immunocytochemistry with specific antibodies.
Gene_expression (expression) of JUN D in spinal cord associated with spinal cord
11) Confidence 0.11 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1761754 Disease Relevance 0 Pain Relevance 0.30
Immunoreactivity decreased to basal levels between 8 and 16 hours. c-FOS and JUN D were expressed in both the superficial and deep dorsal horn; in the latter, c-FOS and JUN D persisted longer.
Gene_expression (expressed) of JUN D in dorsal horn associated with dorsal horn
12) Confidence 0.11 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1761754 Disease Relevance 0.06 Pain Relevance 0.57

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