INT157572

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 10.52
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl12) extracellular region (Ccl12)
Anatomy Link Frequency
monocyte 2
fibroblasts 2
macrophages 1
mast cells 1
Ccl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 201 100.00 Very High Very High Very High
cytokine 138 100.00 Very High Very High Very High
agonist 10 99.26 Very High Very High Very High
Central nervous system 111 96.84 Very High Very High Very High
Inflammation 316 95.12 Very High Very High Very High
medulla 5 86.04 High High
Hyperalgesia 1 75.00 Quite High
allodynia 2 72.76 Quite High
Inflammatory response 36 72.16 Quite High
Spinal cord 16 72.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 50 99.08 Very High Very High Very High
Wound Healing 74 98.44 Very High Very High Very High
Multiple Sclerosis 158 98.32 Very High Very High Very High
Mycobacterial Infection 145 97.80 Very High Very High Very High
Central Nervous System Disease 96 96.84 Very High Very High Very High
Togavirus Infection 75 96.12 Very High Very High Very High
Stress 5 95.36 Very High Very High Very High
INFLAMMATION 333 95.12 Very High Very High Very High
Injury 303 93.04 High High
Viral Meningitis 4 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Gene_expression (expression) of CCL12
1) Confidence 0.70 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.44
The array of ligands for CCR2 includes MCP-1 (CCL2), MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12).
Gene_expression (includes) of CCL12
2) Confidence 0.63 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.50 Pain Relevance 0.26
The array of ligands for CCR2 includes MCP-1 (CCL2), MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12).
Gene_expression (includes) of MCP-5
3) Confidence 0.63 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.50 Pain Relevance 0.26
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Gene_expression (genes) of Ccl12 associated with chemokine
4) Confidence 0.59 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.82 Pain Relevance 0.59
The cytokine IL-12, made up of IL-12p35 and IL-12p40 subunits is crucial for the induction of IFN?
Gene_expression (made) of cytokine IL-12 associated with cytokine
5) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.54 Pain Relevance 0.05
Furthermore, the protein levels of monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, intercellular adhesion molecule-1 and phospholyrated nuclear factor (NF)-?
Gene_expression (levels) of monocyte chemotactic protein in monocyte associated with adhesions
6) Confidence 0.18 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2905642 Disease Relevance 0.82 Pain Relevance 0.08
The protein levels of monocyte chemotactic protein (MCP)-1, IL-6, and intercellular adhesion molecule (ICAM)-1 in the supernatant were determined with mouse MCP-1, IL-6, and ICAM-1 ELISA kits (R&D Systems, Minneapolis, MN).
Spec (determined) Gene_expression (levels) of monocyte chemotactic protein in monocyte associated with adhesions
7) Confidence 0.18 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.10 Pain Relevance 0.07
In this study we showed that BM-MSCs secret high levels of several chemokines such as MIP-1 and 2 and MCP-5, but lower levels of IL6 than dermal fibroblasts.
Gene_expression (secret) of MCP-5 in fibroblasts associated with chemokine
8) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.80 Pain Relevance 0.28
In this study we showed that BM-MSCs secret high levels of several chemokines such as MIP-1 and 2 and MCP-5, but lower levels of IL6 than dermal fibroblasts.
Gene_expression (levels) of MCP-5 in fibroblasts associated with chemokine
9) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.80 Pain Relevance 0.27
These data suggest that Mcpt5 is initially expressed independently of signals from macrophages and neutrophils, but that leukocytes are subsequently responsible for a secondary expression, either directly by expressing Mcp5 themselves, or indirectly by triggering expression in another cell type, possibly supplying cues that reinforce expression by mast cells or prevent their dispersal from the wound site.
Gene_expression (expressing) of Mcp5 in mast cells associated with injury
10) Confidence 0.04 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.82 Pain Relevance 0.22
are induced by murine macrophages in response to both TLR-2 and TLR-4 agonists, however, iNOS, IL-12p40, IP-10 and MCP-5 are produced primarily in response to TLR-4 agonists [130,131].
Gene_expression (produced) of MCP-5 in macrophages associated with agonist
11) Confidence 0.02 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.26 Pain Relevance 0.58

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