INT157573

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 2.93
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf)
Anatomy Link Frequency
endothelial cells 5
Vwf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 38 93.44 High High
allodynia 2 92.24 High High
fibrosis 8 90.44 High High
medulla 113 75.00 Quite High
Hyperalgesia 1 75.00 Quite High
Spinal cord 68 74.48 Quite High
bradykinin 1 73.76 Quite High
ischemia 38 73.60 Quite High
cytokine 29 72.12 Quite High
Pain 1 65.76 Quite High
Disease Link Frequency Relevance Heat
Adhesions 21 96.68 Very High Very High Very High
Hypertension 8 96.32 Very High Very High Very High
Diabetes Mellitus 8 95.48 Very High Very High Very High
Renal Disease 4 93.84 High High
INFLAMMATION 70 93.44 High High
Myocardial Infarction 23 92.80 High High
Neuropathic Pain 2 92.24 High High
Fibrosis 10 90.44 High High
Autoimmune Disease 2 89.20 High High
Systemic Sclerosis 52 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased plasma concentrations of vWf, released from activated endothelial cells, have also been described in other vasculopathies such as hypertension [4] and diabetes [5] and are reported to predict diabetic nephropathy [6], myocardial infarction, and mortality [7,8].
Localization (released) of vWf in endothelial cells associated with diabetes mellitus, renal disease, hypertension and myocardial infarction
1) Confidence 0.69 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.91 Pain Relevance 0.05
At development of this ELISA, the concentration of vWf was determined against standard curves of Haemate (Hoechst, Marbourg, Germany), a commercially available vWf concentrate.
Localization (concentration) of vWf
2) Confidence 0.60 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0 Pain Relevance 0
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (1:500) of von Willebrand Factor
3) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (1:500) of von Willebrand Factor
4) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (used) of von Willebrand Factor
5) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
-synuclein (C20 &211, 1:1000, Santa Cruz Biotech, Santa Cruz, CA), Aquaporin 4 (1:500, Chemicon International, Inc USA, CA), glucose transporter 1 (1:500, Chemicon), von Willebrand Factor (1:500, Dako USA, Carpinteria, CA), iNOS (1:500, Sgima), SMI32 (Sternberger Monoclonal, Lutherville, MD), NeuN (1:1000, Chemicon) were used as suggested by manufacturers.
Localization (1:1000) of von Willebrand Factor
6) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
P-selectin and ICAM-1 were immunolocalized to endothelial cells, and were double labelled with von Willebrand factor.
Localization (labelled) of von Willebrand factor in endothelial cells
7) Confidence 0.45 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.54 Pain Relevance 0.52
For instance, the MAC has been shown to trigger the up-regulation of P-selectin and the secretion of von Willebrand factor in endothelial cells [15].
Localization (secretion) of von Willebrand factor in endothelial cells
8) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.53 Pain Relevance 0.07
cells, including elevated vWF secretion [26].
Localization (secretion) of vWF
9) Confidence 0.27 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0.07
When CD31+/CD144+ cells were cultured in endothelial growth medium, the majority of cells were adherent and expressed endothelial markers (CD31, CD144) at the endothelial cell adherent junctions as well as von Willebrand factor (vWF) located within the cytoplasm (Figure 2B).
Localization (located) of von Willebrand factor in endothelial cell
10) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
When CD31+/CD144+ cells were cultured in endothelial growth medium, the majority of cells were adherent and expressed endothelial markers (CD31, CD144) at the endothelial cell adherent junctions as well as von Willebrand factor (vWF) located within the cytoplasm (Figure 2B).
Localization (located) of vWF in endothelial cell
11) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
Modulation of hemostasis includes the release of plasminogen activator, tissue factor inhibitor, von Willebrand factor, NO, prostacyclin, TXA2, plasminogen-activator inhibitor-1 (PAI-1), and fibrinogen.
Localization (release) of von Willebrand factor
12) Confidence 0.18 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.95 Pain Relevance 0.12

General Comments

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