INT157575

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.05
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl12) extracellular region (Ccl12)
Ccl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 5 99.36 Very High Very High Very High
Inflammation 17 95.12 Very High Very High Very High
cytokine 4 94.20 High High
medulla 10 86.44 High High
allodynia 4 77.44 Quite High
Central nervous system 11 77.12 Quite High
Hyperalgesia 2 75.00 Quite High
Face pain 2 69.68 Quite High
Pain 2 50.96 Quite High
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 99.48 Very High Very High Very High
Togavirus Infection 75 96.12 Very High Very High Very High
Stress 2 95.76 Very High Very High Very High
INFLAMMATION 22 95.12 Very High Very High Very High
Viral Meningitis 4 89.12 High High
Infection 53 87.12 High High
Apoptosis 16 82.60 Quite High
Pressure And Volume Under Development 1 82.04 Quite High
Gliosis 4 81.40 Quite High
Neuropathic Pain 4 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of Gene_expression (expression) of CCL12
1) Confidence 0.63 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.44
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of Gene_expression (expression) of CCL12
2) Confidence 0.63 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.59 Pain Relevance 0.53
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Ccl12 associated with chemokine
3) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.88 Pain Relevance 0.62

General Comments

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