INT157576

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 2
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 2 80.80 Quite High
medulla 5 80.16 Quite High
agonist 5 78.40 Quite High
Hyperalgesia 1 75.00 Quite High
Face pain 1 63.40 Quite High
Pain 1 54.32 Quite High
Inflammatory response 1 41.28 Quite Low
cytokine 3 35.36 Quite Low
Inflammation 3 34.96 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endotoxemia 21 96.40 Very High Very High Very High
Thrombosis 34 94.36 High High
Adhesions 10 93.20 High High
Stress 1 89.48 High High
Hypothermia 46 86.32 High High
Neuropathic Pain 2 80.80 Quite High
Hyperalgesia 1 75.00 Quite High
Facial Pain 1 63.40 Quite High
INFLAMMATION 4 40.92 Quite Low
Sepsis 16 35.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of Localization (verified) of P-selectin
1) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.56 Pain Relevance 0.51
Because P-selectin shed from platelets serves as the main source for circulating P-selectin and platelet activation results in up to 50% secretion of intracellular P-selectin [23], it is reasonable to assume that a major part of the increase in sP-selectin during endotoxemia might also be due to platelet activation.
Positive_regulation (results) of Localization (secretion) of P-selectin in platelet associated with endotoxemia
2) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.63 Pain Relevance 0.07

General Comments

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