INT15758

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Context Info
Confidence 0.23
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.99
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (JUND)
Anatomy Link Frequency
spinal cord 2
JUND (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2 99.48 Very High Very High Very High
opioid receptor 6 99.24 Very High Very High Very High
Spinal cord 2 98.24 Very High Very High Very High
Dorsal horn 8 98.16 Very High Very High Very High
dexamethasone 2 94.44 High High
c fibre 6 92.36 High High
Sciatic nerve 8 91.60 High High
cocaine 1 84.04 Quite High
cytokine 5 81.16 Quite High
mu opioid receptor 1 78.76 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 136 99.76 Very High Very High Very High
Repression 7 99.12 Very High Very High Very High
Neuroblastoma 1 84.40 Quite High
Occupational Lung Diseases 5 80.96 Quite High
Asthma 61 70.24 Quite High
INFLAMMATION 8 60.40 Quite High
Nociception 2 42.24 Quite Low
Cancer 8 11.16 Low Low
Infection 26 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JNK increases the expression of JunD, and JunD acts with NF-?
Positive_regulation (increases) of Gene_expression (expression) of JunD
1) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.28 Pain Relevance 0
This indicates that signaling pathways involving protein kinase C and activator protein 1 (AP-1) transcription factors are important for the specific expression pattern of the mu-opioid receptor gene.
Positive_regulation (important) of Gene_expression (expression) of AP-1 associated with kinase c and opioid receptor
2) Confidence 0.21 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11901219 Disease Relevance 0.08 Pain Relevance 0.62
This is in contrast to other studies carried out in different cells, which have shown GR-mediated AP-1 and NF-?
Positive_regulation (mediated) of Gene_expression (is) of AP-1
3) Confidence 0.13 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.63 Pain Relevance 0.11
Expression of JUN D was increased only after 4 hours.
Positive_regulation (increased) of Gene_expression (Expression) of JUN D
4) Confidence 0.10 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1761754 Disease Relevance 0 Pain Relevance 0.50
We present the first comparative investigation of the basal and transsynaptically induced expression of c-JUN, JUN B, JUN D, c-FOS, FOS B, and KROX-24 proteins in the spinal cord, using immunocytochemistry with specific antibodies.
Positive_regulation (induced) of Gene_expression (expression) of JUN D in spinal cord associated with spinal cord
5) Confidence 0.07 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1761754 Disease Relevance 0 Pain Relevance 0.30

General Comments

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