INT157603

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
articular cartilage 2
Mmp13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 83.28 Quite High
Osteoarthritis 23 73.20 Quite High
agonist 10 68.96 Quite High
Tendonitis 1 67.76 Quite High
Inflammation 48 58.32 Quite High
cytokine 37 36.76 Quite Low
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 38 99.02 Very High Very High Very High
Stress 4 90.80 High High
Anastomotic Leak 4 82.28 Quite High
Osteoarthritis 23 73.20 Quite High
Injury 15 64.88 Quite High
Wound Healing 11 64.40 Quite High
INFLAMMATION 53 58.32 Quite High
Arthritis 11 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BMA resulted in decreased COMP and increased MMP-3 and MMP-13 gene expression.
Positive_regulation (increased) of Gene_expression (expression) of MMP-13
1) Confidence 0.16 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.11
Curiously, MMP-13 (also termed collagenase-3) – a protease specific for type II collagen, a primary ECM component of articular cartilage – was among the few genes whose expression was strongly stimulated (in this case approximately eightfold) by glucosamine.
Positive_regulation (stimulated) of Gene_expression (expression) of MMP-13 in articular cartilage
2) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.07 Pain Relevance 0.04
The GLP-2 ligands showed no effects on mRNA levels for the TIMPs, except for an increase under hypoxic conditions with GLP-2 MMB (data not shown), and MMP-13 expression was not changed but trended downward (Figure 6).
Neg (not) Positive_regulation (changed) of Gene_expression (expression) of MMP-13 associated with hypoxia
3) Confidence 0.08 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.84 Pain Relevance 0.06

General Comments

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