INT157611

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.92
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (RFFL) ligase activity (RFFL) cytoplasm (RFFL)
Anatomy Link Frequency
cleavage 3
RFFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Eae 3 99.84 Very High Very High Very High
aspirin 11 98.28 Very High Very High Very High
Sciatic nerve 1 96.24 Very High Very High Very High
Pain 3 87.28 High High
COX-2 inhibitor 2 61.32 Quite High
cINOD 3 59.48 Quite High
Inflammatory response 1 56.48 Quite High
Inflammation 2 48.12 Quite Low
ischemia 22 32.92 Quite Low
Angina 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 203 99.76 Very High Very High Very High
Injury 7 98.16 Very High Very High Very High
Neuropathic Pain 3 94.72 High High
Death 20 88.80 High High
Pain 3 87.28 High High
Disease 2 84.24 Quite High
Hepatocellular Cancer 9 78.04 Quite High
Squamous Cell Carcinoma 3 75.00 Quite High
Cancer 26 66.24 Quite High
Necrosis 10 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.
Protein_catabolism (proteolysis) of caspases associated with aspirin and apoptosis
1) Confidence 0.05 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.59 Pain Relevance 0.57
Once activated, initiator caspases cleave and activate effector caspases and a proteolytic cascade is initiated.
Protein_catabolism (cleave) of caspases
2) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 1.03 Pain Relevance 0.03
A critical step in the execution of the apoptotic program is cleavage of caspases [36].
Protein_catabolism (cleavage) of caspases in cleavage associated with apoptosis
3) Confidence 0.01 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.51 Pain Relevance 0
Cleavage and activation of caspases is a central event in apoptosis pathways.
Protein_catabolism (Cleavage) of caspases in Cleavage associated with apoptosis
4) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.91 Pain Relevance 0
Energy imbalance can compromise the maintenance of mitochondrial membrane potential, furthering the release of cytochrome C and the subsequent cleavage and activation of caspases.
Protein_catabolism (cleavage) of caspases in cleavage
5) Confidence 0.00 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19170187 Disease Relevance 0.88 Pain Relevance 0.23

General Comments

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