INT15762

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Context Info
Confidence 0.37
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.71
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spike 1
proximal 1
asp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 6 99.36 Very High Very High Very High
tetrodotoxin 3 86.48 High High
addiction 2 75.44 Quite High
projection neuron 2 75.00 Quite High
Piles 27 69.84 Quite High
Dismenorea 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
epidural 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Subarachnoid Hemorrhage 6 99.36 Very High Very High Very High
Disease 10 98.80 Very High Very High Very High
Injury 36 84.08 Quite High
Anorectal Disorders 28 69.84 Quite High
Incontinence 48 69.20 Quite High
Rupture 8 60.44 Quite High
Paralysis 1 56.36 Quite High
Cerebral Aneurysm 21 50.00 Quite Low
Recurrence 12 34.32 Quite Low
Flatulence 2 33.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracellular injection of Cs+ resulted in an abolition of IAs, whereas extracellular application of Ba2+ resulted in a large decrease in the apparent input conductance but relatively little reduction of IAs. 5.
Neg (little) Negative_regulation (reduction) of IAs
1) Confidence 0.37 Published 1991 Journal J. Neurophysiol. Section Abstract Doc Link 1761979 Disease Relevance 0 Pain Relevance 0.08
The time course of removal of inactivation of IAs at -85 to -100 mV was well fitted by a single exponential function with time constant of 91 ms. 4.
Negative_regulation (inactivation) of IAs
2) Confidence 0.37 Published 1991 Journal J. Neurophysiol. Section Abstract Doc Link 1761979 Disease Relevance 0 Pain Relevance 0
However, we believe that a) diagnosing the IAS tear, b) independent suturing of the IAS, and c) being careful when suturing of the proximal portion of the EAS are the most important changes we have introduced.
Negative_regulation (diagnosing) of IAS in proximal
3) Confidence 0.28 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2949785 Disease Relevance 0.33 Pain Relevance 0
Application of low concentrations of 4-aminopyridine (4-AP, 30-100 microM) or dendrotoxin (DTX, 30 nM), which are known to selectively block IAs, reduced both the slope of the ramp potential and the latency to first spike discharge.
Negative_regulation (block) of IAs in spike
4) Confidence 0.21 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 8201411 Disease Relevance 0 Pain Relevance 0.23
We think that after the injection into IAS, spread of the toxin through the EAS is possibly due to the small thickness of IAS and the proximity of EAS to the IAS.
Negative_regulation (proximity) of IAS
5) Confidence 0.05 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC394326 Disease Relevance 0.13 Pain Relevance 0.03
The relatively high prevalence of IAs and aneurysmal SAH place the disease in the group of moderately common disorders.
Negative_regulation (prevalence) of IAs associated with cva and disease
6) Confidence 0.05 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC119849 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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