INT157622

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 22.63
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
microglia 4
lung 4
macrophages 2
retinas 2
brains 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 728 100.00 Very High Very High Very High
midbrain 8 100.00 Very High Very High Very High
agonist 75 99.82 Very High Very High Very High
chemokine 96 98.96 Very High Very High Very High
antagonist 64 98.74 Very High Very High Very High
antidepressant 45 98.16 Very High Very High Very High
substance P 1 95.36 Very High Very High Very High
Cannabinoid 12 94.32 High High
Pain 14 94.00 High High
cytokine 350 93.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 839 100.00 Very High Very High Very High
Pulmonary Disease 774 100.00 Very High Very High Very High
Injury 178 100.00 Very High Very High Very High
Shock 19 100.00 Very High Very High Very High
Bacterial Infection 19 100.00 Very High Very High Very High
Cancer 132 99.84 Very High Very High Very High
Toxicity 17 99.72 Very High Very High Very High
Necrosis 31 99.60 Very High Very High Very High
Infection 167 99.58 Very High Very High Very High
Death 75 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry for TLR2 and TLR4
Positive_regulation (for) of Localization (Immunohistochemistry) of TLR4
1) Confidence 0.48 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.14 Pain Relevance 0
We observed IR-induced loss of retinal neurons in both WT and Tlr4 KO retinas.
Positive_regulation (induced) of Localization (retinas) of Tlr4 in retinas
2) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.77 Pain Relevance 0.18
TLR4 ligand decreased thermal injury-induced bacterial translocation
Positive_regulation (induced) of Localization (translocation) of TLR4 associated with injury
3) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.13 Pain Relevance 0
This possibility is supported by the lack of an effect of (s)CD14 on LIX release after high dose LPS administration, considering that respiratory epithelial cells are important for both PMN influx and LIX secretion [20], [24].
Positive_regulation (important) of Localization (secretion) of LPS in respiratory
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.30 Pain Relevance 0.15
However, it is unclear if this model also results in LPS translocation across the gut.
Positive_regulation (results) of Localization (translocation) of LPS in gut
5) Confidence 0.42 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.51 Pain Relevance 0.11
The purified 48-kDa protein enhanced LPS-induced TNF secretion by alveolar macrophages in vitro (data not shown).
Positive_regulation (enhanced) of Localization (secretion) of LPS in alveolar macrophages
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0 Pain Relevance 0.04
PLGA-PEGPS341 inhibits P. aeruginosa LPS induced CF lung disease
Positive_regulation (induced) of Localization (disease) of LPS in lung associated with pulmonary disease
7) Confidence 0.39 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 1.23 Pain Relevance 0.14
Plant extracts were initially tested against LPS-stimulated release of tumor necrosis factor alpha (TNF-?)
Positive_regulation (stimulated) of Localization (release) of LPS associated with necrosis and cancer
8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2995738 Disease Relevance 0.44 Pain Relevance 0.20
This phenotype is the complete opposite to macrophages in STAT3 conditional KO mice, which are more sensitive to LPS shock and produce more TNF-?
Positive_regulation (sensitive) of Localization (shock) of LPS in macrophages associated with shock
9) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.45 Pain Relevance 0.19
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Positive_regulation (activation) of Localization (translocation) of TLR4 in nucleus
10) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.34 Pain Relevance 0.12
Furthermore, EGCG dramatically inhibited LPS-induced release of IL-6, and a number of chemokines including MIP-1?
Positive_regulation (induced) of Localization (release) of LPS associated with chemokine
11) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.08 Pain Relevance 0.29
In light of the capacity of EGCG in attenuating LPS-induced HMGB1 release, we explored its efficacy in animal model of lethal endotoxemia.
Positive_regulation (induced) of Localization (release) of LPS associated with endotoxemia
12) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.39 Pain Relevance 0.03
and IL-6 was inhibited in TLR4- and TLR2-deficient BMDCs, indicating that both TLR2 and TLR4 participate in the response to H. pylori LPS.
Positive_regulation (response) of Localization (participate) of TLR4
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.12 Pain Relevance 0
Indeed, it was shown that an injection to the intrahippocampus of LPS derivatives (a TLR4 ligand) to the brains of AD mice reduced A?
Positive_regulation (injection) of Localization (intrahippocampus) of LPS in brains associated with disease
14) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.74 Pain Relevance 0.13
Comparison of differential gene expression due to LPS treatment
Positive_regulation (due) of Localization (treatment) of LPS
15) Confidence 0.23 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 0.08 Pain Relevance 0
Administration of PAF attenuated LPS-induced organ injury
Positive_regulation (induced) of Localization (Administration) of LPS associated with injury
16) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.45 Pain Relevance 0.27
To verify the relationship between LPS-induced accumulation of A?
Positive_regulation (accumulation) of Localization (relationship) of LPS
17) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2556656 Disease Relevance 0.76 Pain Relevance 0.09
We first showed that PGE2 levels were lower in BALFs in LPS stimulated cPLA2?
Positive_regulation (stimulated) of Localization (cPLA2) of LPS
18) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.06 Pain Relevance 0.06
In this model of polymicrobial lung infection, intratracheal (IT) injection of both lipopolysaccharide (LPS) and staphylococcal enterotoxin B (SEB) strongly potentiates their toxicity [13].
Positive_regulation (potentiates) of Localization (injection) of LPS in lung associated with toxicity and infection
19) Confidence 0.16 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 1.45 Pain Relevance 0.44
Enhanced release of LPS-induced IL-8, but not PGE2 and LTB4, by COPD BES
Positive_regulation (Enhanced) of Localization (release) of LPS associated with pulmonary disease
20) Confidence 0.11 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 0.67 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox