INT157642

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.68
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (Pik3c3) cell division (Pik3c3) kinase activity (Pik3c3)
Anatomy Link Frequency
muscle 1
Pik3c3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 99.52 Very High Very High Very High
cytokine 34 91.92 High High
Inflammatory response 13 89.28 High High
opioid receptor 2 86.00 High High
tolerance 28 69.20 Quite High
Inflammation 18 13.60 Low Low
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 4 99.20 Very High Very High Very High
Hypersensitivity 10 90.00 High High
INFLAMMATION 30 89.28 High High
Hyperinsulinism 8 87.24 High High
Insulin Resistance 96 78.88 Quite High
Impaired Glucose Tolerance 36 69.84 Quite High
Body Weight 16 57.52 Quite High
Diabetes Mellitus 28 52.64 Quite High
Targeted Disruption 35 50.00 Quite Low
Obesity 32 43.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunoprecipitation analysis showed that p-PKCgamma and Vps34 are present together in molecular complexes.
Gene_expression (present) of Vps34
1) Confidence 0.75 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.39
The treatment with morphine increases PKCgamma and Vps34 levels.
Gene_expression (levels) of Vps34 associated with morphine
2) Confidence 0.65 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
IRS-1–and IRS-2–associated PI3-kinase assays were performed in 4 mg muscle protein extracts according to methods previously described (28).
Gene_expression (assays) of PI3-kinase in muscle
3) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0 Pain Relevance 0
Ala mice also showed an increased association between IRS-1 and the p85 subunit of PI3-kinase, which reflects increased interaction between IRS-1 and PI 3-kinase likely due to the Ser612?
Gene_expression (subunit) of PI3-kinase
4) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.14 Pain Relevance 0.08
IRS-1–associated p85 subunit of PI3-kinase was also 83% higher in Tg IRS-1 Ser?
Gene_expression (subunit) of PI3-kinase
5) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.21 Pain Relevance 0.03
We also detected a 20% increase in IRS-1–associated PI3-kinase activity (Fig. 3D) of Tg IRS-1 Ser?
Gene_expression (activity) of PI3-kinase
6) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.05 Pain Relevance 0
PI3 kinase genetically or pharmacologically enhanced IgE production after OVA allergen immunization [20].
Gene_expression (production) of PI3 kinase associated with immunization
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.28 Pain Relevance 0.17

General Comments

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