INT157645

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.88
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (Pik3c3) cell division (Pik3c3) kinase activity (Pik3c3)
Pik3c3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 4 99.08 Very High Very High Very High
opioid receptor 1 97.04 Very High Very High Very High
bradykinin 3 71.84 Quite High
adenocard 4 71.24 Quite High
Inflammation 2 57.68 Quite High
Bile 2 41.44 Quite Low
Kinase C 39 20.84 Low Low
potassium channel 76 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
action potential duration 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 98.88 Very High Very High Very High
Death 24 96.24 Very High Very High Very High
Insulin Resistance 24 95.48 Very High Very High Very High
Apoptosis 126 92.36 High High
Cancer 238 86.68 High High
Targeted Disruption 17 80.56 Quite High
Hepatocellular Cancer 73 74.88 Quite High
Toxicity 3 69.28 Quite High
Syndrome 1 66.96 Quite High
Obesity 8 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of morphine-induced increase in PKCgamma phosphorylation reduced Vps34 level.
Negative_regulation (reduced) of Vps34 associated with morphine
1) Confidence 0.41 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
In support of this mechanism it has been demonstrated that phosphorylation of Akt is enhanced by IP, especially during reperfusion, and that pharmacological inhibitors of either Akt or PI-3-kinase prevent preconditioning [126,128–130].
Negative_regulation (inhibitors) of PI-3-kinase
2) Confidence 0.03 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.07
M of PI-3 kinase inhibitor LY294002.
Negative_regulation (inhibitor) of PI-3 kinase
3) Confidence 0.02 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.55 Pain Relevance 0
In contrast, blocking PI-3 kinase, p38 kinase and JNK activities by LY294002, SB20358 and SP600125 respectively abolished the phosphorylation of Akt-1, p38 kinase and JNK without affecting the levels of cleaved caspase-3 and -7 (Fig. 4A).
Negative_regulation (blocking) of PI-3 kinase
4) Confidence 0.02 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.55 Pain Relevance 0
Reduced insulin-stimulated glucose transport activity exists with reduced insulin receptor substrate (IRS)-1–associated phosphatidylinositol 3-kinase (PI3-kinase) activity in patients with type 2 diabetes and the offspring of type 2 diabetic parents (2–5).
Negative_regulation (reduced) of PI3-kinase associated with diabetes mellitus
5) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.85 Pain Relevance 0.03
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Negative_regulation (inhibitors) of PI3-kinase associated with death
6) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.87 Pain Relevance 0

General Comments

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