INT157646

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.40

plasma membrane (Oprd1, Prkcc) cytoplasm (Oprd1, Prkcc) cytosol (Prkcc) nucleus (Prkcc) kinase activity (Prkcc) response to stress (Prkcc)

Anatomy Link Frequency neurons 3 Oprd1 (Rattus norvegicus) Prkcc (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 1 100.00 Morphine 4 96.16

|}

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results indicates that opioid receptor activation increases PKCgamma phosphorylation in the neurons and, in turn, upregulates Vps34 during short-term treatment with neurons.

Positive_regulation (activation) of opioid receptor in neurons Positive_regulation (increases) of Phosphorylation (phosphorylation) of PKCgamma in neurons associated with opioid receptor

1) Confidence 0.01 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40

General Comments

This test has worked.