INT15765

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.61
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PON1) extracellular region (PON1) lipid metabolic process (PON1)
Anatomy Link Frequency
liver 1
brain 1
mast cell 1
PON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1 98.16 Very High Very High Very High
Serotonin 3 97.96 Very High Very High Very High
Neurotransmitter 2 97.58 Very High Very High Very High
induced neuropathy 1 96.08 Very High Very High Very High
qutenza 16 88.64 High High
Paracetamol 2 86.72 High High
Central nervous system 1 83.96 Quite High
c fibre 6 78.08 Quite High
methadone 135 72.56 Quite High
Enkephalin 3 64.64 Quite High
Disease Link Frequency Relevance Heat
Edema 4 100.00 Very High Very High Very High
Nicotine Addiction 23 96.00 Very High Very High Very High
Neuropathic Pain 1 95.76 Very High Very High Very High
Rhinitis 6 95.68 Very High Very High Very High
Liver Disease 1 75.12 Quite High
Gastrointestinal Disease 1 74.44 Quite High
Heart Rate Under Development 1 73.40 Quite High
Coronary Artery Disease 2 72.36 Quite High
Cerebrovascular Disease 1 71.40 Quite High
Chronic Renal Failure 1 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement of PON1 and ARE activities
Localization (Measurement) of PON1
1) Confidence 0.75 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827704 Disease Relevance 0.23 Pain Relevance 0.18
Nasal lavage tosyl-L-arginine methyl ester (TAME)-esterase activity, which can be a reflection of mast cell activation, increased vascular permeability or glandular secretion, was also determined.
Localization (secretion) of esterase in mast cell associated with edema
2) Confidence 0.72 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1762079 Disease Relevance 1.02 Pain Relevance 0.43
TAME-esterase activity (presumably a reflection of increased glandular secretion) increased greater than 1000 cpm in 12/21 subjects (designated "TAME-producers"), but this was unrelated to ETS-sensitivity.
Localization (secretion) of TAME-esterase associated with nicotine addiction
3) Confidence 0.63 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1762079 Disease Relevance 1.14 Pain Relevance 0.56
Solubilization of hen brain neurotoxic esterase in dimethylsulfoxide.
Localization (Solubilization) of neurotoxic esterase in brain
4) Confidence 0.13 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 4062936 Disease Relevance 0.10 Pain Relevance 0.10
While this has been documented before in other systems [15], and could be due to media components or residual esterase activity released by the dead schistosomes, the fluorescence measured between live and dead parasites were sufficiently large to detect a significant difference (between 3 min and 12 in both 96-well and 384-well plate formats).
Localization (released) of esterase
5) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910722 Disease Relevance 0 Pain Relevance 0
A third esterase, hydrolase S, is found in rat liver microsomes and rat serum, and may be a serum carboxylesterase secreted from the liver.
Localization (secreted) of esterase in liver
6) Confidence 0.01 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8748931 Disease Relevance 0.07 Pain Relevance 0.15
Measurement of paraoxonase and arylesterase activities
Localization (arylesterase) of arylesterase
7) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 1.05 Pain Relevance 0.09
In particular, there are consistent decreases in protein, DNA, RNA and neurotransmitter content (serotonin, dopamine, norepinephrine) [87, 145, 253, 301, 344], enzymatic protein levels (tyrosine hydroxylase, acetylcholine-esterase, choline acetyltransferase, ornithine decarboxylase) [87, 224, 327, 338, 342, 343], and receptor expression (?
Localization (choline acetyltransferase) of acetylcholine-esterase associated with dopamine, neurotransmitter and serotonin
8) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0 Pain Relevance 0.59

General Comments

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