INT157663

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.92
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Darc) signal transducer activity (Darc)
Anatomy Link Frequency
neutrophils 1
Darc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 46 100.00 Very High Very High Very High
cytokine 35 98.88 Very High Very High Very High
narcan 9 97.56 Very High Very High Very High
antagonist 2 87.84 High High
Opioid 2 87.40 High High
Kinase C 4 71.28 Quite High
Inflammation 27 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 103 98.32 Very High Very High Very High
Neutropenia 18 97.16 Very High Very High Very High
Cold Sores 9 96.48 Very High Very High Very High
Sprains And Strains 2 91.36 High High
Herpes Simplex Virus 2 90.60 High High
Stress 10 89.68 High High
Breast Cancer 4 89.28 High High
Infection 24 88.56 High High
Malaria 2 83.48 Quite High
Immunization 4 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice that were genetically engineered to lack DARC were unable to bind CXC chemokines, which promote tumorogenesis and angiogenesis (Lentsch, 2006).
Negative_regulation (lack) of DARC associated with chemokine
1) Confidence 0.37 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.40 Pain Relevance 0.42
One possibility is that individuals who lack DARC, by which red cells absorb cytokines, are unable to modulate white cell trafficking; hence their neutrophils pool and keep the circulatory ANC low.
Negative_regulation (lack) of DARC in neutrophils associated with chemokine and cytokine
2) Confidence 0.37 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.31 Pain Relevance 0.40
BALB/c mice were divided into four groups; for experimental groups, mice received the glycoprotein D1 (gD1) DNA vaccine alone or in combination with the adjuvant NLX.
Negative_regulation (received) of glycoprotein D1 associated with narcan
3) Confidence 0.11 Published 2009 Journal Int. Immunol. Section Abstract Doc Link 19174474 Disease Relevance 0.95 Pain Relevance 0.50
Thus, although the antigen receptor numbers do not decrease, their functions are altered.
Neg (not) Negative_regulation (decrease) of antigen receptor
4) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.26 Pain Relevance 0.14

General Comments

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