INT15768

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Context Info
Confidence 0.71
First Reported 1990
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 9.31
Pain Relevance 8.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
macrophages 1
Blood 1
livers 1
B-cell 1
brain 1
Il1a (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 16 99.64 Very High Very High Very High
cytokine 30 99.62 Very High Very High Very High
Paracetamol 33 99.48 Very High Very High Very High
Pain 14 99.42 Very High Very High Very High
narcan 11 99.12 Very High Very High Very High
Inflammation 66 98.80 Very High Very High Very High
Enkephalin 1 98.08 Very High Very High Very High
Morphine 18 97.60 Very High Very High Very High
Inflammatory response 6 96.96 Very High Very High Very High
dexamethasone 4 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 10 99.42 Very High Very High Very High
INFLAMMATION 70 98.80 Very High Very High Very High
Hepatotoxicity 6 98.76 Very High Very High Very High
Infection 11 98.64 Very High Very High Very High
Severe Combined Immunodeficiency 17 98.52 Very High Very High Very High
Pressure And Volume Under Development 12 98.28 Very High Very High Very High
Neuropathic Pain 10 98.24 Very High Very High Very High
Cancer 84 97.44 Very High Very High Very High
Sprains And Strains 4 96.72 Very High Very High Very High
Depression 1 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the activity of drugs of abuse was studied on IL-1 alpha and TNF production by activated murine macrophages.
Gene_expression (production) of IL-1 alpha in macrophages
1) Confidence 0.71 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8407054 Disease Relevance 0.10 Pain Relevance 0.43
Although ketoconazole at 40 mg/kg and IL-1 alpha at 25 micrograms/kg alone each produced approximately 50% clonogenic cell kill, a combined treatment (IL-1 alpha 1 h after ketoconazole) resulted in surviving fractions of approximately 1.5%.
Gene_expression (produced) of IL-1 alpha
2) Confidence 0.67 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2369744 Disease Relevance 0.68 Pain Relevance 0.17
At the same time the serum levels of interleukin-1 alpha (IL-1 alpha) were increased.
Gene_expression (levels) of IL-1 alpha
3) Confidence 0.60 Published 2002 Journal Cytokine Section Abstract Doc Link 12182845 Disease Relevance 0.53 Pain Relevance 0.65
These findings suggest that an increase in serum levels of IL-1 alpha plays an important role in the anti-inflammatory effect of morphine.
Gene_expression (levels) of IL-1 alpha associated with inflammation and morphine
4) Confidence 0.60 Published 2002 Journal Cytokine Section Abstract Doc Link 12182845 Disease Relevance 0.60 Pain Relevance 0.66
At the same time the serum levels of interleukin-1 alpha (IL-1 alpha) were increased.
Gene_expression (levels) of interleukin-1 alpha
5) Confidence 0.60 Published 2002 Journal Cytokine Section Abstract Doc Link 12182845 Disease Relevance 0.53 Pain Relevance 0.65
Blood samples obtained after endotoxin revealed no difference in levels of TNF-alpha (5477 +/- 742 vs. 6514 +/- 652 pg/ml) or IL-1 alpha (546 +/- 72 vs. 603 +/- 121 pg/ml) in the sham vs. heated mice.
Gene_expression (levels) of IL-1 alpha in Blood
6) Confidence 0.58 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7858059 Disease Relevance 0.50 Pain Relevance 0.29
Administration of APAP resulted in an immediate reduction in body temperature as well as elevated serum levels of IL-1 alpha and TNF-alpha that reached a peak at 12 and 16 hr, respectively.
Gene_expression (levels) of IL-1 alpha in body associated with paracetamol
7) Confidence 0.57 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7597709 Disease Relevance 0.36 Pain Relevance 0.78
Here, it is shown that radioiodinated murine IL-1 beta and especially murine IL-1 alpha are even more rapidly transported into the brain of the mouse than is radioiodinated human IL-1 alpha after i.v. injection.
Gene_expression (transported) of IL-1 alpha in brain
8) Confidence 0.57 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1762091 Disease Relevance 0 Pain Relevance 0.05
IL-1 alpha pretreatment equally protected against the hepatotoxicity of acetaminophen and CCl(4) in both strains, and suppressed the total microsomal P450 and P450 enzyme-catalyzed testosterone hydroxylation to a similar extent.
Gene_expression (pretreatment) of IL-1 alpha associated with paracetamol, hepatotoxicity and sprains and strains
9) Confidence 0.38 Published 2000 Journal Toxicology Section Abstract Doc Link 10924799 Disease Relevance 0.57 Pain Relevance 0.63
IL-1 alpha and IL-1 beta were expressed to similar extents in livers of untreated IL-1ra KO and WT mice.
Gene_expression (expressed) of IL-1 alpha in livers
10) Confidence 0.34 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.34 Pain Relevance 1.12
pathways (Il1a, Tnfrsf19, Traf1, Card10) suggest that these pathways, which are known to activate p38 MAPK, may be involved in the expression of Cebpb/NF?
Gene_expression (pathways) of Il1a
11) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.05 Pain Relevance 0.08
Recombinant human interleukin-1 alpha (rHu-IL-1 alpha) has been indicated to produce central antinociception in the mouse phenylquinone writhing test, the antinociception being unaffected by naloxone.
Gene_expression (produce) of interleukin-1 alpha associated with antinociception and narcan
12) Confidence 0.30 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8365458 Disease Relevance 0 Pain Relevance 0.42
Recombinant human interleukin-1 alpha (rHu-IL-1 alpha) has been indicated to produce central antinociception in the mouse phenylquinone writhing test, the antinociception being unaffected by naloxone.
Gene_expression (produce) of rHu-IL-1 alpha associated with antinociception and narcan
13) Confidence 0.30 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8365458 Disease Relevance 0 Pain Relevance 0.42
By using ELISAs specific for mouse cytokines, large amounts of IL-1-alpha, TNF-alpha, IL-6, and IFN-gamma were detected in the peritoneal washings of huPBL-SCID mice 1 day after intraperitoneal injection.
Gene_expression (detected) of IL-1-alpha associated with severe combined immunodeficiency and cytokine
14) Confidence 0.28 Published 1995 Journal Transplantation Section Abstract Doc Link 8525526 Disease Relevance 0.76 Pain Relevance 0.13
To further investigate the role of IL-1 in different pain states, gene-disrupted mice lacking both IL-1alpha and IL-1beta genes (IL-1alphabeta (-/-)) were characterized in inflammatory, neuropathic, and post-operative pain models.
Neg (lacking) Gene_expression (lacking) of IL-1alphabeta associated with pain, inflammation and neuropathic pain
15) Confidence 0.27 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16256210 Disease Relevance 1.22 Pain Relevance 0.75
To further investigate the role of IL-1 in different pain states, gene-disrupted mice lacking both IL-1alpha and IL-1beta genes (IL-1alphabeta (-/-)) were characterized in inflammatory, neuropathic, and post-operative pain models.
Neg (lacking) Gene_expression (lacking) of IL-1alpha associated with pain, inflammation and neuropathic pain
16) Confidence 0.27 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16256210 Disease Relevance 1.15 Pain Relevance 0.69
Ocular IL-1 alpha, IL-6, and TNF-alpha were detected over an 11 day time period.
Gene_expression (detected) of IL-1 alpha
17) Confidence 0.27 Published 1994 Journal J Ocul Pharmacol Section Abstract Doc Link 8207331 Disease Relevance 1.04 Pain Relevance 0.26
Nevertheless, there is still transcriptional evidence for the presence of other mesodermal derivatives such as hematopoietic derivatives with the increased expression of IL1A (10–20 fold), toll like receptor 3 (TLR 3, 3 fold), skeletogenic genes such as RUNX1 (4 fold), sclerostosis (SOST, 8.7 fold), osteoprotogerin (TNFSFR11, 7 fold).
Gene_expression (expression) of IL1A
18) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0 Pain Relevance 0
B) pathway were repressed, including interleukin 1 alpha, Tnf receptor-associated factor 1, interleukin-1 receptor-associated kinase 2, myeloid differentiation primary response gene 88, toll-interacting protein, TNFAIP3-interacting protein 1, B-cell leukemia/lymphoma 10, and NF-?
Gene_expression (repressed) of interleukin 1 alpha in B-cell associated with leukemia and lymphatic system cancer
19) Confidence 0.13 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.82 Pain Relevance 0.12
Injection of D with IL-I to mice produced a 1.5 lower content of C-reactive protein (CRP) than in the control.
Gene_expression (produced) of IL-I
20) Confidence 0.01 Published 1993 Journal Biull Eksp Biol Med Section Abstract Doc Link 7509645 Disease Relevance 0.08 Pain Relevance 0.45

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