INT157687

Context Info Confidence 0.62 First Reported 2008 Last Reported 2010 Negated 6 Speculated 0 Reported most in Body Documents 9 Total Number 10 Disease Relevance 4.96 Pain Relevance 3.27

transport (Akt1) aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)

Anatomy Link Frequency kidney cortex 2 neural 2 Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 154 100.00 antagonist 21 99.70 Opioid 28 99.48 narcan 2 99.26 opioid receptor 168 98.90 Antinociceptive 10 97.20 Spinal nerve ligature 7 95.48 COX-2 inhibitor 3 92.72 Kinase C 78 87.84 allodynia 3 86.56

Disease Link Frequency Relevance Heat Hypertrophy 9 98.92 Obesity 176 97.42 Cancer 212 89.60 Aging 124 89.36 Neuropathic Pain 8 88.12 Metastasis 121 87.44 Disease 10 82.80 INFLAMMATION 18 82.44 Pain 7 81.40 Diabetes Mellitus 16 80.12

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Linalool did not induce significant changes in Akt expression and phopshorylation though a trend toward an increased ratio of phosphorylated versus total Akt was observed in SNL animals treated with linalool, in comparison to SNL alone or sham.

Neg (not) Regulation (changes) of Gene_expression (expression) of Akt associated with spinal nerve ligature

1) Confidence 0.62 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607973 Disease Relevance 0.90 Pain Relevance 1.47

MOR activates Akt via Gi/o and PI3K [33], [34] as well as regulating Akt expression in neural cells [35], [36].

Regulation (regulating) of Gene_expression (expression) of Akt in neural associated with opioid receptor

2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.51

The level of Akt in the cultures treated with 50 ?

Regulation (cultures) of Gene_expression (level) of Akt

3) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.30 Pain Relevance 0.04

Naloxone, an opioid antagonist, inhibits the effects of morphine on Akt-nNOS activation, indicating the involvement of MORs (not shown).

Regulation (effects) of Gene_expression (activation) of Akt associated with antagonist, narcan, opioid and morphine

4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.96

Of note, these authors detected a decrease in PKB/Akt phosphorylation on Ser473 with no apparent change in PKB/Akt expression in kidney cortex of Irs2-/- mice (Fig. 6A, C[24]).

Neg (no) Regulation (change) of Gene_expression (expression) of PKB/Akt in kidney cortex

5) Confidence 0.31 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.12 Pain Relevance 0

Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).

Neg (no) Regulation (changes) of Gene_expression (levels) of phosphorylated-Akt

6) Confidence 0.26 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.65 Pain Relevance 0

Our results revealed that either obesity or age independently dampened the phosphorylation of Akt and its downstream signaling molecule eNOS without affecting expression of Akt and eNOS.

Neg (without) Regulation (affecting) of Gene_expression (expression) of Akt associated with obesity

7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.92 Pain Relevance 0

Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).

Neg (no) Regulation (changes) of Gene_expression (levels) of Akt

8) Confidence 0.22 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.64 Pain Relevance 0

Expression of insulin-like growth factor-1 and phosphorylation of Akt, mammalian target of rapamycin, and p70S6K were increased following synergist ablation, but were not affected by NS-398.

Neg (not) Regulation (affected) of Gene_expression (Expression) of Akt

9) Confidence 0.19 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19176887 Disease Relevance 0.77 Pain Relevance 0.25

is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2).

Regulation (regulated) of Gene_expression (/) of kinases-1

10) Confidence 0.05 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2440494 Disease Relevance 0.66 Pain Relevance 0.04

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