INT157687

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2008
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.96
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
kidney cortex 2
neural 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 154 100.00 Very High Very High Very High
antagonist 21 99.70 Very High Very High Very High
Opioid 28 99.48 Very High Very High Very High
narcan 2 99.26 Very High Very High Very High
opioid receptor 168 98.90 Very High Very High Very High
Antinociceptive 10 97.20 Very High Very High Very High
Spinal nerve ligature 7 95.48 Very High Very High Very High
COX-2 inhibitor 3 92.72 High High
Kinase C 78 87.84 High High
allodynia 3 86.56 High High
Disease Link Frequency Relevance Heat
Hypertrophy 9 98.92 Very High Very High Very High
Obesity 176 97.42 Very High Very High Very High
Cancer 212 89.60 High High
Aging 124 89.36 High High
Neuropathic Pain 8 88.12 High High
Metastasis 121 87.44 High High
Disease 10 82.80 Quite High
INFLAMMATION 18 82.44 Quite High
Pain 7 81.40 Quite High
Diabetes Mellitus 16 80.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Linalool did not induce significant changes in Akt expression and phopshorylation though a trend toward an increased ratio of phosphorylated versus total Akt was observed in SNL animals treated with linalool, in comparison to SNL alone or sham.
Neg (not) Regulation (changes) of Gene_expression (expression) of Akt associated with spinal nerve ligature
1) Confidence 0.62 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607973 Disease Relevance 0.90 Pain Relevance 1.47
MOR activates Akt via Gi/o and PI3K [33], [34] as well as regulating Akt expression in neural cells [35], [36].
Regulation (regulating) of Gene_expression (expression) of Akt in neural associated with opioid receptor
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.51
The level of Akt in the cultures treated with 50 ?
Regulation (cultures) of Gene_expression (level) of Akt
3) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.30 Pain Relevance 0.04
Naloxone, an opioid antagonist, inhibits the effects of morphine on Akt-nNOS activation, indicating the involvement of MORs (not shown).


Regulation (effects) of Gene_expression (activation) of Akt associated with antagonist, narcan, opioid and morphine
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.96
Of note, these authors detected a decrease in PKB/Akt phosphorylation on Ser473 with no apparent change in PKB/Akt expression in kidney cortex of Irs2-/- mice (Fig. 6A, C[24]).
Neg (no) Regulation (change) of Gene_expression (expression) of PKB/Akt in kidney cortex
5) Confidence 0.31 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.12 Pain Relevance 0
Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).


Neg (no) Regulation (changes) of Gene_expression (levels) of phosphorylated-Akt
6) Confidence 0.26 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.65 Pain Relevance 0
Our results revealed that
                   either obesity or age independently dampened the phosphorylation of Akt and its
                   downstream signaling molecule eNOS without affecting expression of Akt and eNOS.
                   
Neg (without) Regulation (affecting) of Gene_expression (expression) of Akt associated with obesity
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.92 Pain Relevance 0
Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).


Neg (no) Regulation (changes) of Gene_expression (levels) of Akt
8) Confidence 0.22 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.64 Pain Relevance 0
Expression of insulin-like growth factor-1 and phosphorylation of Akt, mammalian target of rapamycin, and p70S6K were increased following synergist ablation, but were not affected by NS-398.
Neg (not) Regulation (affected) of Gene_expression (Expression) of Akt
9) Confidence 0.19 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19176887 Disease Relevance 0.77 Pain Relevance 0.25
is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2).
Regulation (regulated) of Gene_expression (/) of kinases-1
10) Confidence 0.05 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2440494 Disease Relevance 0.66 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox