INT157687
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Linalool did not induce significant changes in Akt expression and phopshorylation though a trend toward an increased ratio of phosphorylated versus total Akt was observed in SNL animals treated with linalool, in comparison to SNL alone or sham. | |||||||||||||||
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MOR activates Akt via Gi/o and PI3K [33], [34] as well as regulating Akt expression in neural cells [35], [36]. | |||||||||||||||
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The level of Akt in the cultures treated with 50 ? | |||||||||||||||
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Naloxone, an opioid antagonist, inhibits the effects of morphine on Akt-nNOS activation, indicating the involvement of MORs (not shown).
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Of note, these authors detected a decrease in PKB/Akt phosphorylation on Ser473 with no apparent change in PKB/Akt expression in kidney cortex of Irs2-/- mice (Fig. 6A, C[24]). | |||||||||||||||
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Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).
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Our results revealed that
either obesity or age independently dampened the phosphorylation of Akt and its downstream signaling molecule eNOS without affecting expression of Akt and eNOS. | |||||||||||||||
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Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).
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Expression of insulin-like growth factor-1 and phosphorylation of Akt, mammalian target of rapamycin, and p70S6K were increased following synergist ablation, but were not affected by NS-398. | |||||||||||||||
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is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2). | |||||||||||||||
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General Comments
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