INT15769

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 146
Total Number 149
Disease Relevance 114.51
Pain Relevance 75.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
macrophage 14
neutrophil 5
leukocyte 4
brain 4
frontal cortex 4
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 639 100.00 Very High Very High Very High
cytokine 502 100.00 Very High Very High Very High
Analgesic 93 100.00 Very High Very High Very High
chemokine 64 100.00 Very High Very High Very High
Nerve growth factor 27 100.00 Very High Very High Very High
Antinociceptive 25 100.00 Very High Very High Very High
Glutamate 17 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
intrathecal 12 99.98 Very High Very High Very High
analgesia 18 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 636 100.00 Very High Very High Very High
Stress 98 100.00 Very High Very High Very High
Necrosis 85 100.00 Very High Very High Very High
Cancer 76 100.00 Very High Very High Very High
Adhesions 48 100.00 Very High Very High Very High
Lung Injury 60 99.92 Very High Very High Very High
Hyperalgesia 150 99.88 Very High Very High Very High
Wallerian Degeneration 61 99.88 Very High Very High Very High
Diabetes Mellitus 39 99.80 Very High Very High Very High
Urological Neuroanatomy 42 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that both exogenous and endogenous opioids regulate IL-1 beta production by microglial cells in the mixed brain cell cultures.
Gene_expression (production) of IL-1 beta in brain associated with endogenous opioid
1) Confidence 0.78 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7499497 Disease Relevance 0 Pain Relevance 0.77
Our objective was to characterize the molecular mechanisms responsible for the hepatic inflammatory response to time-limited TNF-alpha and IL-1beta expression.
Gene_expression (expression) of IL-1beta associated with inflammatory response
2) Confidence 0.75 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.29 Pain Relevance 0.22
The pattern of chemokine expression is consistent with the delay in neutrophil recruitment to the footpad: T. maculosa venom stimulated an early production of IL-1beta, IL-6, and MCP-1, but was unable to induce an effective early TNF-alpha and KC release.
Gene_expression (production) of IL-1beta in neutrophil associated with chemokine
3) Confidence 0.75 Published 2008 Journal Toxicon Section Abstract Doc Link 18586048 Disease Relevance 0.53 Pain Relevance 0.20
Administration of ketamine alone did not influence TNF-alpha, IL-1beta, or IL-6 mRNA production.
Gene_expression (production) of IL-1beta associated with ketamine
4) Confidence 0.75 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.14 Pain Relevance 0.70
METHODS: Col1-IL-1betaXAT mice and GFAP-IL-1betaXAT mice were injected with the feline immunodeficiency virus (FIV) (Cre) vector in the right and left temporomandibular joints (TMJs), or in the cisterna magna, respectively, to induce IL-1beta expression in the dorsal horns of the spinal horn.
Gene_expression (expression) of IL-1beta in horn
5) Confidence 0.75 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18821694 Disease Relevance 0.18 Pain Relevance 0
A significantly increased expression of TNF-alpha and IL-1beta was observed in both strains.
Gene_expression (expression) of IL-1beta associated with sprains and strains
6) Confidence 0.75 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.47 Pain Relevance 0.42
Overexpression of spinal IL-1beta in the recently developed GFAP-IL-1betaXAT somatic mosaic model of neuroinflammation led to development of arthritis-like pathology accompanied by increased pain-like behavior.
Gene_expression (Overexpression) of IL-1beta in spinal
7) Confidence 0.75 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18821694 Disease Relevance 0.11 Pain Relevance 0
RESULTS: None of the specimens produced any TNF-alpha, IL-1beta, granulocyte-macrophage colony-stimulating factor, or leukotriene B4.
Gene_expression (produced) of IL-1beta in macrophage
8) Confidence 0.75 Published 2003 Journal Spine Section Body Doc Link 14673370 Disease Relevance 0 Pain Relevance 0
Murine nucleus pulposus synthesizes increased amounts of IL-1beta, IL-6, IL-10, and granulocyte-macrophage colony-stimulating factor in response to lipopolysaccharide stimulation.
Gene_expression (synthesizes) of IL-1beta in macrophage
9) Confidence 0.75 Published 2003 Journal Spine Section Body Doc Link 14673370 Disease Relevance 0.07 Pain Relevance 0
In addition, i.p. treatment with SB225002 significantly attenuated the increase in MPO activity or the elevation of IL-1beta, TNFalpha or KC levels following carrageenan injection.
Gene_expression (levels) of IL-1beta associated with chemokine and urological neuroanatomy
10) Confidence 0.75 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19264522 Disease Relevance 0.60 Pain Relevance 0.78
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Gene_expression (expression) of IL-1beta associated with paracetamol
11) Confidence 0.75 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
Our studies in wild-type mice, as well as the Col1-IL1beta(XAT) mouse model of osteoarthritis, demonstrated an inverse correlation between IL-1beta and TGFbeta expression in the TMJ.
Gene_expression (expression) of IL-1beta in TMJ associated with snapping jaw and osteoarthritis
12) Confidence 0.75 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19587162 Disease Relevance 1.18 Pain Relevance 0.75
APAP alone induced in a dose-dependent manner the production of TNFalpha and IL-1beta in this cell line.
Gene_expression (production) of IL-1beta associated with paracetamol
13) Confidence 0.75 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.34 Pain Relevance 1.06
When LPS was added to APAP-treated cells, the increase in TNFalpha and IL-1beta production observed was higher than the sum of cytokine amounts produced with each agent alone, suggesting a synergistic mechanism.
Gene_expression (production) of IL-1beta associated with paracetamol and cytokine
14) Confidence 0.75 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.32 Pain Relevance 1.10
When inhibiting MAPKs using pharmacological inhibitors, we showed that p38MAPK inhibition abrogated the synergistic effect of APAP and LPS found for TNFalpha production but not for IL-1beta production.
Gene_expression (production) of IL-1beta associated with paracetamol
15) Confidence 0.75 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.26 Pain Relevance 1.32
Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.
Gene_expression (production) of IL-1beta associated with paracetamol
16) Confidence 0.75 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.19 Pain Relevance 1.24
TNF-alpha and IL-1beta production in the supernatant were, on average, 30% lower in the ispilateral group than in the contralateral group.
Gene_expression (production) of IL-1beta
17) Confidence 0.75 Published 2005 Journal Br J Anaesth Section Body Doc Link 15863437 Disease Relevance 0 Pain Relevance 0
The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.
Gene_expression (production) of IL-1beta in neutrophil
18) Confidence 0.75 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.32 Pain Relevance 0.03
No effects were observed on IL-1beta or MCP-1 expression.
Gene_expression (expression) of IL-1beta
19) Confidence 0.75 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.25 Pain Relevance 1.07
Prolonged expression of the cytokines TNF-alpha and IL-1beta increases hepatic leukocyte-endothelial cell interactions.
Gene_expression (expression) of IL-1beta in leukocyte associated with cytokine
20) Confidence 0.75 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.52 Pain Relevance 0.22

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