INT15771

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 38
Disease Relevance 3.16
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nrg1) extracellular space (Nrg1) cell morphogenesis (Nrg1)
plasma membrane (Nrg1) cytoplasm (Nrg1)
Anatomy Link Frequency
peripheral nerves 3
radial 2
Schwann cells 2
dorsal root ganglia 1
synapses 1
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
conotoxin 2 99.68 Very High Very High Very High
Chronic pancreatitis 4 98.96 Very High Very High Very High
Pain 3 98.80 Very High Very High Very High
Central nervous system 36 97.60 Very High Very High Very High
Delta opioid receptors 3 96.48 Very High Very High Very High
Peripheral nervous system 36 93.68 High High
Neurotransmitter 72 91.88 High High
Demyelination 16 91.00 High High
anesthesia 7 90.00 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 18 99.58 Very High Very High Very High
Pancreatitis 4 98.96 Very High Very High Very High
Pain 3 98.80 Very High Very High Very High
Diabetes Mellitus 41 93.36 High High
Schizophrenia 95 92.68 High High
Liver Disease 1 92.52 High High
Demyelinating Disease 17 91.00 High High
Death 36 84.48 Quite High
Lifespan 18 81.44 Quite High
Targeted Disruption 104 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When NRG1 is presented to Schwann cells in the context of cell-cell contact, type III but not type I NRG1 regulates P0 gene expression.
Gene_expression (presented) of NRG1 in Schwann cells
1) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16554459 Disease Relevance 0.15 Pain Relevance 0.12
Increasing evidence from genetic linkage studies has identified both the NRG1 (Stefansson et al., 2002; Harrison and Law, 2006) and the ?
Gene_expression (identified) of NRG1
2) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.31 Pain Relevance 0.19
m axonal length; and Nrg1-ECD, 13.20 ± 2.72 clusters/100-?
Gene_expression (length) of Nrg1
3) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
We also demonstrate that Type III Nrg1 back signaling activates a phosphatidylinositol 3-kinase signaling pathway and that activation of this pathway is required for the insertion of preexisting ?
Gene_expression (signaling) of Nrg1
4) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
Additionally, it has been shown that Type III Nrg1 also functions as a receptor, in that Type III Nrg1–ErbB interaction results in signaling within the Type III Nrg1–expressing cell (Bao et al., 2003, 2004).
Gene_expression (expressing) of Nrg1
5) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.11 Pain Relevance 0.04
Because we do not see effects of Type III Nrg1 back signaling on ?
Gene_expression (effects) of Nrg1
6) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.15
Stimulation of Type III Nrg1 back signaling increases surface expression of ?
Gene_expression (back) of Nrg1
7) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Activation of presynaptic Type III Nrg1 signaling, either by postsynaptic ErbB4 (as shown in Fig.
Gene_expression (presynaptic) of Nrg1
8) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.03
Prior work has shown that presynaptic Type III Nrg1 is critical for establishing stable interactions with postsynaptic partners and, ultimately, for the survival of neuromuscular synapses as well as for glia development and myelination (Wolpowitz et al., 2000; Michailov et al., 2004; Taveggia et al., 2005; Chen et al., 2006).
Gene_expression (presynaptic) of Nrg1 in synapses
9) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Acute stimulation of Type III Nrg1 back signaling increases the number of ?
Gene_expression (back) of Nrg1
10) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
Stimulation of Type III Nrg1 back signaling induces an increase in axonal surface ?
Gene_expression (back) of Nrg1
11) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.05
Presynaptic Type III Neuregulin1-ErbB signaling targets ?
Gene_expression (Presynaptic) of Neuregulin1
12) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Title Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
Because we do not see effects of Type III Nrg1 back signaling on ?
Gene_expression (signaling) of Nrg1
13) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.15
As a result, Type III Nrg1 back signaling, by regulating presynaptic ?
Gene_expression (back) of Nrg1
14) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.05
Presynaptic Type III Neuregulin1-ErbB signaling targets ?
Gene_expression (targets) of Neuregulin1
15) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Title Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
7* nAChR levels; Type III Nrg1 functioning as a receptor can regulate insertion of preformed ?
Gene_expression (levels) of Nrg1
16) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
It is worth noting that these risk alleles at the NRG1 locus also have been associated with increased expression of Type I and IV Nrg1 (Law et al., 2006).
Gene_expression (expression) of Nrg1
17) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.32 Pain Relevance 0.04
Reduction of Type III Nrg1 expression results in decreased axonal ?
Gene_expression (expression) of Nrg1
18) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.03
Subsets of primary sensory neurons within the dorsal root ganglia (DRG) express Type III Nrg1 and ?
Gene_expression (express) of Nrg1 in dorsal root ganglia
19) Confidence 0.52 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Similarly, KU-32 also prevented the NRG1-induced decrease in the expression of the compact myelin protein zero, P0 (Figure 2C).
Gene_expression (expression) of NRG1
20) Confidence 0.46 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.41 Pain Relevance 0.15

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