INT157719

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.41
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C6) extracellular region (C6) molecular_function (C6)
Anatomy Link Frequency
vesicles 2
dura mater 1
PMNs 1
C6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 3 99.38 Very High Very High Very High
narcan 2 95.84 Very High Very High Very High
MU agonist 1 91.12 High High
Spinal cord 286 90.12 High High
cytokine 20 87.12 High High
Antinociceptive 7 86.84 High High
Pain 5 81.60 Quite High
Central nervous system 145 76.32 Quite High
Delta opioid receptors 1 75.48 Quite High
Kinase C 20 75.36 Quite High
Disease Link Frequency Relevance Heat
Skin Ulcer 2 94.56 High High
Eczema 2 93.56 High High
Disease 82 92.20 High High
Spinal Cord Injury 350 90.60 High High
Edema 10 89.72 High High
Increased Venous Pressure Under Development 30 89.24 High High
Telangiectasia 4 88.64 High High
Cardiovascular Disease 86 86.00 High High
Pain 3 81.60 Quite High
Injury 287 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The posterior shift of the spinal cord at C5 was correlated with the amount of the dura mater at C4, C5, and C6 levels.
Gene_expression (levels) of C6 in dura mater
1) Confidence 0.67 Published 2009 Journal Spine Section Body Doc Link 19179922 Disease Relevance 0 Pain Relevance 0
Expression of C1q, C3, C4, C5, C6, C7, C9, CD59, Crry, and GADPH mRNAs in cultured PMNs was assayed by rt-PCR.
Gene_expression (Expression) of C6
2) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0
The lack of terminal complement mRNAs in cultured PMNs may not have been unexpected because several studies have suggested that C6 and C7 are not actively synthesized by PMNs in culture, but were likely presynthesized in PMNs during differentiation in the bone marrow, stored in cytoplasmic vesicles, and subsequently released during circulation [18,34].
Neg (not) Gene_expression (synthesized) of C6 in vesicles
3) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0.03
As shown in Figure 3 by rt-PCR, both unstimulated PMNs and stimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C6, C7, and C9 in culture.
Gene_expression (expressed) of C6
4) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.05 Pain Relevance 0.19
The lack of terminal complement mRNAs in cultured PMNs may not have been unexpected because several studies have suggested that C6 and C7 are not actively synthesized by PMNs in culture, but were likely presynthesized in PMNs during differentiation in the bone marrow, stored in cytoplasmic vesicles, and subsequently released during circulation [18,34].
Neg (not) Gene_expression (synthesized) of C6 in vesicles
5) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0.03
Stimulated or unstimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C5, C6, C7 or C9 in culture.
Gene_expression (expressed) of C6 in PMNs
6) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2443364 Disease Relevance 1.32 Pain Relevance 0.37
Groups C5 and C6 were combined in our study (‘C5&C6’) because of the limited number (n = 114) of samples available (Table 1).
Gene_expression (combined) of C6
7) Confidence 0.22 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 0.98 Pain Relevance 0
Groups C5 and C6 were combined in our study (‘C5&C6’) because of the limited number (n = 114) of samples available (Table 1).
Gene_expression (combined) of C6
8) Confidence 0.22 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 0.98 Pain Relevance 0
Therefore, our study suggests that not only opioid receptors may be involved in behavioral effects of cUENK6.
Gene_expression (effects) of cUENK6 associated with opioid receptor
9) Confidence 0.18 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19376576 Disease Relevance 0.08 Pain Relevance 1.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox