INT15775

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Context Info
Confidence 0.69
First Reported 1974
Last Reported 2011
Negated 4
Speculated 2
Reported most in Abstract
Documents 50
Total Number 53
Disease Relevance 22.38
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
plasma 28
heart 2
kidney 2
vascular system 1
cardiovascular system 1
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 106 100.00 Very High Very High Very High
cytokine 21 100.00 Very High Very High Very High
Calcitonin gene-related peptide 7 99.80 Very High Very High Very High
pain flank 1 98.96 Very High Very High Very High
qutenza 2 98.74 Very High Very High Very High
beta blocker 14 98.56 Very High Very High Very High
Calcium channel 15 98.28 Very High Very High Very High
c fibre 1 98.28 Very High Very High Very High
Catecholamine 6 98.04 Very High Very High Very High
antagonist 80 97.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 105 100.00 Very High Very High Very High
Heart Rate Under Development 19 100.00 Very High Very High Very High
Hypertension 158 99.90 Very High Very High Very High
Chronic Renal Failure 704 99.84 Very High Very High Very High
Infection 146 99.72 Very High Very High Very High
Pressure And Volume Under Development 121 99.64 Very High Very High Very High
Pressure Volume 2 Under Development 11 99.62 Very High Very High Very High
Increased Venous Pressure Under Development 45 99.58 Very High Very High Very High
Diabetes Mellitus 339 99.12 Very High Very High Very High
Flank Pain 1 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The beta-blockers with intrinsic sympathomimetic activity such as pindolol were found to increase renin activity when given alone, but blocked an increase in renin activity when given prior to isoproterenol.
Positive_regulation (increase) of renin associated with beta blocker
1) Confidence 0.69 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6171684 Disease Relevance 0 Pain Relevance 0.14
Renin activity was significantly increased by the administration of hydralazine (1 mg/kg, i.p.), furosemide (20 mg/kg, i.v.), and isoproterenol (0.1 mg/kg, s.c.).
Positive_regulation (increased) of Renin
2) Confidence 0.69 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6171684 Disease Relevance 0 Pain Relevance 0.11
The beta-blockers with intrinsic sympathomimetic activity such as pindolol were found to increase renin activity when given alone, but blocked an increase in renin activity when given prior to isoproterenol.
Positive_regulation (increase) of renin associated with beta blocker
3) Confidence 0.69 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6171684 Disease Relevance 0 Pain Relevance 0.14
Many clinical and laboratory studies have demonstrated that it is the estrogen content of ovulation inhibitors that is responsible for the increased plasma renin activity.
Positive_regulation (responsible) of plasma renin in plasma
4) Confidence 0.54 Published 1974 Journal Med Klin Section Abstract Doc Link 4374645 Disease Relevance 1.24 Pain Relevance 0.07
Many clinical and laboratory studies have demonstrated that it is the estrogen content of ovulation inhibitors that is responsible for the increased plasma renin activity.
Positive_regulation (increased) of plasma renin in plasma
5) Confidence 0.54 Published 1974 Journal Med Klin Section Abstract Doc Link 4374645 Disease Relevance 1.24 Pain Relevance 0.07
Additionally, activation of Src family members by G-protein-coupled receptors may increase ERK1/2 phosphorylation via activation of the renin angiotensin system (Ras) [17, 18] or via transactivation of the EGFR [26].
Positive_regulation (activation) of renin
6) Confidence 0.49 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583213 Disease Relevance 0 Pain Relevance 0.06
Plasma renin activity, however, was not increased during chronic therapy with pinacidil monotherapy.
Neg (not) Positive_regulation (increased) of Plasma renin in Plasma
7) Confidence 0.48 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2466178 Disease Relevance 0.05 Pain Relevance 0.13
Captopril administration increased renin equally [plasma renin activity (PRA): +/+ 9.3 +/- 2.2 vs. 50.1 +/- 10.9; -/- 13.7 +/- 1.5 vs. 43.9 +/- 6.6 ng ANG I x ml(-1) x h(-1); renal renin concentration: +/+ 11.8 +/- 1.7 vs. 35.3 +/- 3.9; -/- 13.0 +/- 3.0 vs. 27.8 +/- 2.7 ng ANG I x mg protein(-1) x h(-1); n = 6; P < 0.05 with or without captopril].
Positive_regulation (increased) of renin in plasma
8) Confidence 0.47 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.06 Pain Relevance 0.09
Because renin increases are mediated by cAMP, we also examined whether increased renin is mediated by the prostaglandin E(2) receptor EP(2) subtype, which is coupled to G(s) and increases cAMP.
Spec (whether) Positive_regulation (increased) of renin
9) Confidence 0.47 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.08 Pain Relevance 0.08
Because renin increases are mediated by cAMP, we also examined whether increased renin is mediated by the prostaglandin E(2) receptor EP(2) subtype, which is coupled to G(s) and increases cAMP.
Spec (examined) Positive_regulation (increases) of renin
10) Confidence 0.47 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.09 Pain Relevance 0.09
Plasma renin activity was significantly elevated 4 hours after the administration of the 0.75- and 1.0-mg doses, but showed no significant change at 0.5 mg.
Positive_regulation (elevated) of Plasma renin in Plasma
11) Confidence 0.47 Published 1996 Journal J Clin Pharmacol Section Abstract Doc Link 8739023 Disease Relevance 0.31 Pain Relevance 0.20
Plasma renin activity again increased 4 hours after administration.
Positive_regulation (increased) of Plasma renin in Plasma
12) Confidence 0.47 Published 1996 Journal J Clin Pharmacol Section Abstract Doc Link 8739023 Disease Relevance 0.33 Pain Relevance 0.20
The up-regulation of renin was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting experiments in the dose dependent treatments and the time course observation after aluminium citrate injection.
Positive_regulation (regulation) of renin
13) Confidence 0.47 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0 Pain Relevance 0.09
After a single dose of aluminium, an up-regulation of renin gene was found by DNA sequencing of the products of differential display analysis.
Positive_regulation (regulation) of renin
14) Confidence 0.47 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0 Pain Relevance 0.09
An operation was performed because of complaint of flank pain in the first case and hypertension associated with elevated plasma renin activity in the second case.
Positive_regulation (elevated) of plasma renin in plasma associated with pain flank and hypertension
15) Confidence 0.46 Published 1988 Journal Hinyokika Kiyo Section Abstract Doc Link 3051940 Disease Relevance 0.88 Pain Relevance 0.10
In conscious hypertensive dogs LF 2.0254 (0.1 and 0.3 mg/kg per os) decreased blood pressure and concomitantly increased heart rate and plasma renin activity.
Positive_regulation (increased) of plasma renin in plasma associated with heart rate under development, pressure volume 2 under development and hypertension
16) Confidence 0.36 Published 1990 Journal Fundam Clin Pharmacol Section Abstract Doc Link 2112508 Disease Relevance 0.30 Pain Relevance 0.20
Concerning pathogenesis of ovulation-inhibitor-related hypertension, changes (increases) in the renin-angiotensin-aldosterone system are assumed to play a major role (almost all women on the pill exhibit elevated renin-angiotensin-aldosterone activity).
Positive_regulation (elevated) of renin-angiotensin-aldosterone associated with pressure and volume under development
17) Confidence 0.36 Published 1974 Journal Med Klin Section Abstract Doc Link 4374645 Disease Relevance 1.20 Pain Relevance 0.08
This study provides definitive evidence that metabolites of COX-2 rather than COX-1 mediate ACEI-induced renin increases.
Positive_regulation (increases) of renin
18) Confidence 0.34 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0 Pain Relevance 0.04
Captopril administration increased renin equally [plasma renin activity (PRA): +/+ 9.3 +/- 2.2 vs. 50.1 +/- 10.9; -/- 13.7 +/- 1.5 vs. 43.9 +/- 6.6 ng ANG I x ml(-1) x h(-1); renal renin concentration: +/+ 11.8 +/- 1.7 vs. 35.3 +/- 3.9; -/- 13.0 +/- 3.0 vs. 27.8 +/- 2.7 ng ANG I x mg protein(-1) x h(-1); n = 6; P < 0.05 with or without captopril].
Positive_regulation (increased) of renin in plasma
19) Confidence 0.34 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.06 Pain Relevance 0.09
Unlike ACE inhibitors, ARBs and other antihypertensive agents that cause an increase in plasma renin activity, aliskiren directly inhibits the catalytic activity of renin, thus reducing plasma renin activity and, in turn, the production of Ang II and aldosterone [63].
Positive_regulation (increase) of plasma renin in plasma
20) Confidence 0.33 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.31 Pain Relevance 0.16

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