INT15776

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Context Info
Confidence 0.74
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.90
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
nucleus 3
chondrocytes 1
neurons 1
thalamus 1
hippocampus 1
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 10 100.00 Very High Very High Very High
Pain 9 100.00 Very High Very High Very High
Thalamus 9 100.00 Very High Very High Very High
Hippocampus 6 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
vagus nerve 12 98.54 Very High Very High Very High
Spinal cord 13 98.32 Very High Very High Very High
qutenza 9 98.16 Very High Very High Very High
Dorsal horn 2 98.12 Very High Very High Very High
rheumatoid arthritis 18 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 98.96 Very High Very High Very High
Cancer 16 98.64 Very High Very High Very High
Rheumatoid Arthritis 19 95.36 Very High Very High Very High
Nociception 1 94.08 High High
Stress 14 92.32 High High
Death 21 92.12 High High
INFLAMMATION 57 91.36 High High
Disease 6 91.00 High High
Injury 23 89.52 High High
Arthritis 20 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vagotomy induced the expression of c-JUN and JUN D in the nodose ganglion, dorsal motor nucleus of the vagus nerve and nucleus ambiguus, whereas JUN B was not expressed in these areas, c-JUN and JUN D appeared after 10 h in the nodose ganglion and after 24 h in the dorsal motor nucleus of the vagus nerve with a maximum of immunoreactivity after 48 h.
Localization (appeared) of JUN in nucleus associated with ganglion cysts and vagus nerve
1) Confidence 0.74 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.20 Pain Relevance 0.25
Vagotomy induced the expression of c-JUN and JUN D in the nodose ganglion, dorsal motor nucleus of the vagus nerve and nucleus ambiguus, whereas JUN B was not expressed in these areas, c-JUN and JUN D appeared after 10 h in the nodose ganglion and after 24 h in the dorsal motor nucleus of the vagus nerve with a maximum of immunoreactivity after 48 h.
Localization (appeared) of JUN in nucleus associated with ganglion cysts and vagus nerve
2) Confidence 0.74 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.20 Pain Relevance 0.25
Jun, Fos and Krox in the hippocampus after noxious stimulation: simultaneous-input-dependent expression and nuclear speckling.
Localization (speckling) of Jun in hippocampus associated with hippocampus
3) Confidence 0.68 Published 2001 Journal Brain Res. Section Title Doc Link 11251193 Disease Relevance 0.09 Pain Relevance 0.44
Jun, Fos and Krox in the thalamus after C-fiber stimulation: coincident-input-dependent expression, expression across somatotopic boundaries, and nucleolar translocation.
Localization (translocation) of Jun in thalamus associated with c fibre, nociceptor and thalamus
4) Confidence 0.67 Published 2001 Journal Neuroscience Section Title Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.92
Surprisingly, upon stimulation only the jun B transcript is augmented, being co-localized with Fos in a subset of neurons of the medial dorsal horn.
Localization (localized) of jun in neurons associated with dorsal horn
5) Confidence 0.64 Published 1991 Journal Oncogene Section Abstract Doc Link 1900356 Disease Relevance 0.29 Pain Relevance 0.35
, AP-1, and nuclear factor-kappa-B (NF-?
Localization (factor-kappa-B) of AP-1
6) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 1.47 Pain Relevance 0.64
In time course analyses, we examined a panel of transcription factors [18],
                       [28],
                       [29], and established the kinetics of nuclear
                   accumulation of p-WOX1, c-Jun, ATF3, JNK, NF-?
Localization (accumulation) of Jun
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.44 Pain Relevance 0.03
AP-1 can then translocate into the nucleus to promote transcription of downstream genes.
Localization (translocate) of AP-1 in nucleus
8) Confidence 0.11 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.59 Pain Relevance 0.18
In previous work, however, glucosamine did not appear to inhibit nuclear translocation of activator protein 1 following stimulation of chondrocytes with IL-1 [22]; however, the relationship between this signaling pathway and glucosamine has not been studied in detail.
Localization (translocation) of activator protein 1 in chondrocytes
9) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.38 Pain Relevance 0.11
It blocks the translocation of nuclear factor kappa B (NF-kB), activator protein 1 (AP-1), and signal transducer and activator of transcription (STAT3) signaling pathway that are required for carcinogenesis.
Localization (translocation) of activator protein 1
10) Confidence 0.02 Published 2010 Journal Indian J Cancer Section Abstract Doc Link 20071791 Disease Relevance 0.24 Pain Relevance 0.52

General Comments

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