INT15777

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 9
Speculated 0
Reported most in Abstract
Documents 66
Total Number 72
Disease Relevance 25.97
Pain Relevance 26.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pvalb)
Anatomy Link Frequency
neurons 17
interneurons 5
nucleus 4
tooth pulp 3
cortex 3
Pvalb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 122 100.00 Very High Very High Very High
Calcitonin gene-related peptide 95 100.00 Very High Very High Very High
Neuropeptide 90 100.00 Very High Very High Very High
Somatostatin 68 100.00 Very High Very High Very High
Glutamate 42 100.00 Very High Very High Very High
Enkephalin 30 100.00 Very High Very High Very High
mu opioid receptor 21 100.00 Very High Very High Very High
Cholecystokinin 4 100.00 Very High Very High Very High
interneuron 3 100.00 Very High Very High Very High
nociceptor 113 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 294 99.82 Very High Very High Very High
Generalized Anxiety Disorder 3 99.68 Very High Very High Very High
Cough 504 99.62 Very High Very High Very High
Renal Cell Carcinoma 28 99.40 Very High Very High Very High
Convulsion 6 99.40 Very High Very High Very High
Nociception 76 99.04 Very High Very High Very High
Stress 177 99.02 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 6 98.64 Very High Very High Very High
Lissencephaly 2 98.48 Very High Very High Very High
Malignant Neoplastic Disease 2 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is strongly suggested that muscle contractile activity plays an important role on the expression of parvalbumin in thymic myoid cells.
Gene_expression (expression) of parvalbumin in muscle
1) Confidence 0.78 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1762694 Disease Relevance 0.09 Pain Relevance 0.11
In the TG, PEP 19-IR was found in 34% of primary sensory neurons retrogradely labeled from the molar tooth pulp. 80% of PEP 19-IR tooth pulp TG neurons coexpressed parvalbumin-IR.
Gene_expression (coexpressed) of parvalbumin in tooth pulp associated with trigeminal ganglion
2) Confidence 0.75 Published 1999 Journal Brain Res. Section Abstract Doc Link 10556647 Disease Relevance 0.32 Pain Relevance 0.29
Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.
Gene_expression (expressing) of parvalbumin in interneurons associated with pyramidal cell, neuropeptide, somatostatin, agonist and cholecystokinin
3) Confidence 0.75 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10377334 Disease Relevance 0 Pain Relevance 0.51
Morphological studies have revealed that at least two types of parvalbumin-expressing interneurons in the hippocampus: large, multiple-polar round shaped, axon-somal basket cells and smaller, spindle shaped, axo-axonic chandelier cells [28].
Gene_expression (expressing) of parvalbumin in basket cells associated with hippocampus
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943478 Disease Relevance 0 Pain Relevance 0.52
Expression of parvalbumin (PV) and transient receptor potential vanilloid (TRPV1) receptors in the lumbar dorsal root ganglion neurons (DRG) was evaluated in control animals and in rats after acute carageenan-induced knee joint inflammation.
Gene_expression (Expression) of parvalbumin in dorsal root ganglion associated with ganglion cysts, inflammation, root ganglion neuron and arthritis
5) Confidence 0.75 Published 2009 Journal Physiol Res Section Abstract Doc Link 19397388 Disease Relevance 0.40 Pain Relevance 0.27
Calbindin and parvalbumin were not detected in the same cells.
Neg (not) Gene_expression (detected) of parvalbumin
6) Confidence 0.70 Published 1990 Journal Neuroscience Section Abstract Doc Link 2247226 Disease Relevance 0 Pain Relevance 0.33
Electron microscopy showed that the immunoreactive products of calbindin or parvalbumin were mostly in the dendrites or cell bodies.
Gene_expression (products) of parvalbumin in dendrites
7) Confidence 0.70 Published 1990 Journal Neuroscience Section Abstract Doc Link 2247226 Disease Relevance 0 Pain Relevance 0.41
Parvalbumin was not found together with these peptides.
Neg (not) Gene_expression (found) of Parvalbumin
8) Confidence 0.70 Published 1990 Journal Neuroscience Section Abstract Doc Link 2247226 Disease Relevance 0 Pain Relevance 0.41
To test the hypothesis that this atypical expression of parvalbumin is induced by seizure-correlated hyperactivity in the entorhinohippocampal loop, we investigated whether it is dependent on extrinsic afferents to the entorhinal cortex.
Gene_expression (expression) of parvalbumin in cortex associated with convulsion and attention deficit hyperactivity disorder
9) Confidence 0.65 Published 2000 Journal Neuroscience Section Abstract Doc Link 11029535 Disease Relevance 0.29 Pain Relevance 0.10
These results indicate that spontaneous local activity, but not activity mediated by extrinsic afferents, is an essential factor for the expression of parvalbumin in the entorhinal cortex of the Mongolian gerbil.
Gene_expression (expression) of parvalbumin in cortex
10) Confidence 0.65 Published 2000 Journal Neuroscience Section Abstract Doc Link 11029535 Disease Relevance 0.20 Pain Relevance 0.13
Blockade of spontaneous local activity with the sodium-channel blocker tetrodotoxin, however, considerably reduced the number of parvalbumin-expressing neurons in culture.
Gene_expression (expressing) of parvalbumin in neurons associated with tetrodotoxin
11) Confidence 0.65 Published 2000 Journal Neuroscience Section Abstract Doc Link 11029535 Disease Relevance 0.23 Pain Relevance 0.14
A species-specific property of the Mongolian gerbil is the expression of the calcium-binding protein parvalbumin in the perforant path where it is predominantly concentrated in nerve terminals.
Gene_expression (expression) of parvalbumin in nerve
12) Confidence 0.65 Published 2000 Journal Neuroscience Section Abstract Doc Link 11029535 Disease Relevance 0.27 Pain Relevance 0.04
Species-specific expression of parvalbumin in the entorhinal cortex of the Mongolian gerbil: dependence on local activity but not extrinsic afferents.
Gene_expression (expression) of parvalbumin in cortex associated with addiction
13) Confidence 0.65 Published 2000 Journal Neuroscience Section Title Doc Link 11029535 Disease Relevance 0.25 Pain Relevance 0.11
In these cultures, parvalbumin-expressing neurons demonstrated their characteristic features like in vivo.
Gene_expression (expressing) of parvalbumin in neurons
14) Confidence 0.65 Published 2000 Journal Neuroscience Section Abstract Doc Link 11029535 Disease Relevance 0.25 Pain Relevance 0.13
Conversely, a half of parvalbumin- (53%) and calbindin D-28k-IR (55%) neurons coexpressed PEP 19-IR.
Gene_expression (coexpressed) of parvalbumin in neurons
15) Confidence 0.65 Published 1999 Journal Brain Res. Section Abstract Doc Link 10556647 Disease Relevance 0.49 Pain Relevance 0.29
We hypothesized that a subset of mu opioid receptor-expressing neurons in the subiculum also would express the calcium binding protein, parvalbumin, and could be labeled with VVA.
Gene_expression (express) of parvalbumin in neurons associated with mu opioid receptor
16) Confidence 0.62 Published 1998 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 9630678 Disease Relevance 0 Pain Relevance 0.55
Chavkin, Vicia villosa agglutinin labels a subset of neurons coexpressing both the mu opioid receptor and parvalbumin in the developing rat subiculum, Dev.
Gene_expression (coexpressing) of parvalbumin in subiculum associated with mu opioid receptor
17) Confidence 0.62 Published 1998 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 9630678 Disease Relevance 0 Pain Relevance 0.15
This protocol was designed to triple-label neurons expressing the mu opioid receptor, parvalbumin and the carbohydrate group, N-acetylgalactosamine (which binds VVA [S.E.
Gene_expression (expressing) of parvalbumin in neurons associated with mu opioid receptor
18) Confidence 0.62 Published 1998 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 9630678 Disease Relevance 0 Pain Relevance 0.51
These studies therefore suggest that VA deficiency, opioid exposure, and HIV infection alone and in combination may potentially alter neuronal metabolic activity and induce cellular stress, resulting in the observed changes in levels of parvalbumin expression.
Gene_expression (expression) of parvalbumin in neuronal associated with stress, acquired immune deficiency syndrome or hiv infection, opioid and infection
19) Confidence 0.60 Published 2010 Journal J. Neurovirol. Section Abstract Doc Link 20113193 Disease Relevance 1.00 Pain Relevance 0.52
In contrast, numbers of neurons that expressed the calcium-binding protein parvalbumin, which is a marker interneurons that express the inhibitory neurotransmitter gamma-aminobutyric acid (GABAergic neurons) were decreased for wild-type (Wt) rats on the VA-deficient diet and for Wt rats treated with morphine.
Gene_expression (expressed) of parvalbumin in GABAergic neurons associated with neurotransmitter, gabaergic and morphine
20) Confidence 0.60 Published 2010 Journal J. Neurovirol. Section Abstract Doc Link 20113193 Disease Relevance 1.27 Pain Relevance 0.60

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