INT15778

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Context Info
Confidence 0.27
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pvalb)
Anatomy Link Frequency
neuronal 2
neurons 2
muscle 2
Pvalb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 128 99.78 Very High Very High Very High
dorsal root ganglion 58 99.20 Very High Very High Very High
Hippocampus 14 98.90 Very High Very High Very High
Neuronal excitability 4 95.98 Very High Very High Very High
GABAergic 1 94.14 High High
Pyramidal cell 5 84.32 Quite High
Action potential 3 81.92 Quite High
tetrodotoxin 2 70.16 Quite High
depression 32 17.64 Low Low
long-term potentiation 19 17.32 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 58 99.20 Very High Very High Very High
Paralysis 1 93.96 High High
Drug Induced Neurotoxicity 24 20.84 Low Low
Depression 32 17.64 Low Low
Cognitive Disorder 25 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is strongly suggested that muscle contractile activity plays an important role on the expression of parvalbumin in thymic myoid cells.
Regulation (role) of Gene_expression (expression) of parvalbumin in muscle
1) Confidence 0.27 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1762694 Disease Relevance 0.09 Pain Relevance 0.11
Given that GABAergic disinhibition may serve as a mechanism for generalized enhancement of neuronal excitability and parvalbumin-expressing interneurons have been reported to play a key role in coordinating of neuronal network excitability of the hippocampus [28], we then examined whether neonatal DEX treatment affects parvalbumin-expressing interneurons.
Spec (whether) Regulation (affects) of Gene_expression (expressing) of parvalbumin in neuronal associated with neuronal excitability, gabaergic, hippocampus and dexamethasone
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943478 Disease Relevance 0 Pain Relevance 0.54
Next we examined the effect of oxaliplatin on the expression of parvalbumin, a marker of large DRG neurons.
Spec (examined) Regulation (effect) of Gene_expression (expression) of parvalbumin in neurons associated with dorsal root ganglion
3) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.46 Pain Relevance 0.23

General Comments

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