INT157797

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) DNA binding (Smad3)
protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)
Anatomy Link Frequency
PSC 2
Smad3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 18 77.28 Quite High
antagonist 1 74.12 Quite High
Inflammation 27 23.44 Low Low
cytokine 8 19.52 Low Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 12 98.56 Very High Very High Very High
Soft Tissue Injuries 1 84.56 Quite High
Targeted Disruption 40 81.68 Quite High
Fibrosis 15 79.76 Quite High
Pulmonary Fibrosis 8 77.28 Quite High
Adult Respiratory Distress Syndrome 2 70.88 Quite High
Lung Injury 11 66.16 Quite High
INFLAMMATION 33 23.44 Low Low
Necrosis 1 15.64 Low Low
Cancer 1 15.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of EC-SOD leads to downregulation of this signaling pathway as evidenced by both reduced expression and phosphorylation of Smad3.
Negative_regulation (downregulation) of Phosphorylation (phosphorylation) of Smad3
1) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.83 Pain Relevance 0.17
Halofuginone did not affect TGFbeta levels in cerulein-treated mice but inhibited serum response factor synthesis and Smad3 phosphorylation.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Smad3
2) Confidence 0.35 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Halofuginone inhibits Smad3 phosphorylation and increases c-Jun N-terminal kinase phosphorylation, leading to the inhibition of PSC activation and consequent prevention of fibrosis.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of Smad3 in PSC
3) Confidence 0.35 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0.05 Pain Relevance 0

General Comments

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