INT157800

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Srf) nucleus (Srf) DNA binding (Srf)
transcription factor binding (Srf) cytoplasm (Srf)
Anatomy Link Frequency
stellate cell 1
Srf (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 6 50.00 Quite Low
addiction 2 50.00 Quite Low
agonist 6 11.84 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 6 96.20 Very High Very High Very High
Injury 3 95.00 High High
Shock 151 94.24 High High
Stress 23 90.20 High High
Liver Cancer 2 22.68 Low Low
Aging 1 6.44 Low Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Pancreatitis 2 5.00 Very Low Very Low Very Low
Heat Stress Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SRF is a ubiquitously expressed transcription factor that plays a role in regulating early response genes to various stimuli including healing after tissue injury [32].
Gene_expression (expressed) of SRF associated with injury
1) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.72 Pain Relevance 0
Halofuginone did not affect TGFbeta levels in cerulein-treated mice but inhibited serum response factor synthesis and Smad3 phosphorylation.
Gene_expression (synthesis) of serum response factor
2) Confidence 0.25 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0.07 Pain Relevance 0
Levels of prolyl 4-hydroxylase beta (P4Hbeta), cytoglobin/stellate cell activation-associated protein (Cygb/STAP), transgelin, tissue inhibitors of metalloproteinases, serum response factor, transforming growth factor beta (TGFbeta), Smad3, and pancreatitis-associated protein 1 (PAP-1) were determined by immunohistochemistry.
Spec (determined) Gene_expression (Levels) of serum response factor in stellate cell
3) Confidence 0.25 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0.10 Pain Relevance 0

General Comments

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