INT157804

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 8.15
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) DNA binding (Smad3)
protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)
Anatomy Link Frequency
MDA-MB-231 3
4T1 2
endothelial cells 1
PSC 1
plaques 1
Smad3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 102 79.04 Quite High
fibrosis 41 73.88 Quite High
antagonist 26 70.72 Quite High
Osteoarthritis 91 66.68 Quite High
metalloproteinase 3 28.48 Quite Low
cytokine 32 20.16 Low Low
agonist 14 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 245 99.36 Very High Very High Very High
Disorder Of Lipid Metabolism 21 98.86 Very High Very High Very High
Apoptosis 359 95.68 Very High Very High Very High
Injury 23 95.16 Very High Very High Very High
Breast Cancer 271 94.72 High High
Targeted Disruption 55 92.00 High High
Metastasis 295 90.88 High High
Cancer 506 86.40 High High
Soft Tissue Injuries 1 81.16 Quite High
Fibrosis 39 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of EC-SOD leads to downregulation of this signaling pathway as evidenced by both reduced expression and phosphorylation of Smad3.
Phosphorylation (phosphorylation) of Smad3
1) Confidence 0.77 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.75 Pain Relevance 0.13
Phosphorylated Smad2 and Smad3, the effectors of the TGF-?
Phosphorylation (Phosphorylated) of Smad3
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.09 Pain Relevance 0
Halofuginone did not affect TGFbeta levels in cerulein-treated mice but inhibited serum response factor synthesis and Smad3 phosphorylation.
Phosphorylation (phosphorylation) of Smad3
3) Confidence 0.51 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Halofuginone inhibits Smad3 phosphorylation and increases c-Jun N-terminal kinase phosphorylation, leading to the inhibition of PSC activation and consequent prevention of fibrosis.
Phosphorylation (phosphorylation) of Smad3 in PSC
4) Confidence 0.51 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0 Pain Relevance 0
The phosphorylated Smad2 and Smad3 then form a complex with Smad4 and translocate to the nucleus [29,30].
Phosphorylation (phosphorylated) of Smad3 in nucleus
5) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.08 Pain Relevance 0.04
Atorvastatin increased Smad3 phosphorylation associated to elevated PAI-1 expression, collagen deposition and SMA staining, indicating that the TGF-?
Phosphorylation (phosphorylation) of Smad3
6) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.56 Pain Relevance 0.03
In endothelial cells, but also in chondrocytes, activation of the ALK5 route is followed by Smad2 or Smad3 phosphorylation while ALK1 has been found to result in phosphorylation of Smad1, Smad5, or Smad8 [29-31].
Phosphorylation (phosphorylation) of Smad3 in endothelial cells
7) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.29 Pain Relevance 0.09
Antibodies employed were: phosphorylated Smad3 (p-Smad3; Abcam for immunohistochemistry, ), pSmad3 kindly donated by Dr.
Phosphorylation (phosphorylated) of Smad3
8) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0 Pain Relevance 0
-induced Smad2 and Smad3 phosphorylation and Smad-dependent gene transcription.
Phosphorylation (phosphorylation) of Smad3
9) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.52 Pain Relevance 0.03
RhoA blockade increased Smad3 phosphorylation induced by TGF-?
Phosphorylation (phosphorylation) of Smad3
10) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.44 Pain Relevance 0
In atherosclerotic lesions atorvastatin increased Smad3 phosphorylation and TRII expression compared to non-treated mice.
Phosphorylation (phosphorylation) of Smad3 associated with atherosclerosis
11) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.72 Pain Relevance 0
Pretreatment with Y-27632, an inhibitor of the downstream RhoA mediator ROCK, enhanced Smad-dependent transcription and Smad3 phosphorylation caused by TGF-?
Phosphorylation (phosphorylation) of Smad3
12) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.23 Pain Relevance 0
The in vivo relevance of these findings was assessed in an experimental model of atherosclerosis in apolipoprotein E deficient mice: Treatment with Atorvastatin increased Smad3 phosphorylation and TRII overexpression, associated to elevated ECM deposition in the VSMCs within atheroma plaques, while apoptosis was not detected.


Phosphorylation (phosphorylation) of Smad3 in plaques associated with atherosclerosis, apoptosis and disorder of lipid metabolism
13) Confidence 0.34 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597201 Disease Relevance 0.88 Pain Relevance 0.03
Further investigation revealed that doxorubicin stimulated the phosphorylation of Smad2 and Smad3 in both 4T1 and MDA-MB-231 cells.
Phosphorylation (phosphorylation) of Smad3 in 4T1
14) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.95 Pain Relevance 0
-mediated phosphorylation of Smad2 and Smad3 in both murine 4T1 and human MDA-MB-231 cells.
Phosphorylation (phosphorylation) of Smad3 in MDA-MB-231
15) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.61 Pain Relevance 0
1 treatment (2 ng/ml), doxorubicin treatment (25 nM) also stimulated phosphorylation of Smad2 and Smad3 proteins in both 4T1 and MDA-MB-231 (Figure 2) cells, which was inhibited by the addition of the TGF?
Phosphorylation (phosphorylation) of Smad3 in 4T1
16) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.51 Pain Relevance 0
1 treatment (2 ng/ml), doxorubicin treatment (25 nM) also stimulated phosphorylation of Smad2 and Smad3 proteins in both 4T1 and MDA-MB-231 (Figure 2) cells, which was inhibited by the addition of the TGF?
Phosphorylation (phosphorylation) of Smad3 in MDA-MB-231
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.51 Pain Relevance 0
Further investigation revealed that doxorubicin stimulated the phosphorylation of Smad2 and Smad3 in both 4T1 and MDA-MB-231 cells.
Phosphorylation (phosphorylation) of Smad3 in MDA-MB-231
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.95 Pain Relevance 0

General Comments

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