INT157816

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.73
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
macrophages 8
DCs 2
cornea 2
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 60 99.40 Very High Very High Very High
Inflammation 211 99.26 Very High Very High Very High
adenocard 1 97.48 Very High Very High Very High
cytokine 66 96.00 Very High Very High Very High
mu opioid receptor 7 94.88 High High
agonist 7 94.60 High High
chemokine 18 89.28 High High
Sicca syndrome 21 86.00 High High
Inflammatory response 16 80.68 Quite High
opioid receptor 1 71.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 193 99.26 Very High Very High Very High
Pulmonary Disease 104 98.20 Very High Very High Very High
Eye Disease 11 96.88 Very High Very High Very High
Pulmonary Emphysema 32 94.24 High High
Disorders Of The Lacrimal System 37 89.88 High High
Disease 33 88.36 High High
Syndrome 22 86.00 High High
Metaplasia 22 83.24 Quite High
Airway Obstruction 4 77.84 Quite High
Nicotine Addiction 36 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, EM1 treatment resulted in less activation of p38 MAPK and more activation of ERK signaling in lipopolysaccharide-stimulated DCs.
Positive_regulation (resulted) of Positive_regulation (activation) of DCs in DCs
1) Confidence 0.33 Published 2009 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 19189219 Disease Relevance 0 Pain Relevance 0.54
In our investigation of the afferent arm of the immune loop, we observed an accumulation of DCs in the limbus and mobilization of activated DCs into the cornea.
Positive_regulation (accumulation) of Positive_regulation (activated) of DCs in cornea
2) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.57 Pain Relevance 0.15
Indeed, daily treatment with the antagonist prevented the significant CS-induced increase in macrophages and DCs that was seen in control animals.
Positive_regulation (induced) of Positive_regulation (increase) of DCs in macrophages associated with antagonist
3) Confidence 0.16 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.43 Pain Relevance 0.12
However, further research is needed to unravel the precise mechanism by which signalling through the tachykinin NK1 receptor causes the increased accumulation of macrophages and DCs into the airway lumen upon cigarette smoke exposure and to clearly demonstrate a possible beneficial effect of tachykinin receptor antagonists in people suffering from COPD.


Positive_regulation (causes) of Positive_regulation (accumulation) of DCs in macrophages associated with pulmonary disease and antagonist
4) Confidence 0.15 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 1.13 Pain Relevance 0.30
In this mouse model of COPD, CS-exposure resulted in an increase of inflammatory cells in the lavage fluid whereby a role for the tachykinin NK1 receptor in macrophage and DCs accumulation was demonstrated.
Positive_regulation (role) of Positive_regulation (accumulation) of DCs in macrophage associated with pulmonary disease and inflammation
5) Confidence 0.15 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.48 Pain Relevance 0.29
However, further research is needed to unravel the precise mechanism by which signalling through the tachykinin NK1 receptor causes the increased accumulation of macrophages and DCs into the airway lumen upon cigarette smoke exposure and to clearly demonstrate a possible beneficial effect of tachykinin receptor antagonists in people suffering from COPD.


Positive_regulation (increased) of Positive_regulation (accumulation) of DCs in macrophages associated with pulmonary disease and antagonist
6) Confidence 0.15 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 1.12 Pain Relevance 0.30
Stimulation of human pDCs or monocytic DCs with synthetic TLR7 ligands induces the secretion of interferon (IFN)-?
Positive_regulation (induces) of Positive_regulation (Stimulation) of pDCs
7) Confidence 0.13 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.11
Stimulation of human pDCs or monocytic DCs with synthetic TLR7 ligands induces the secretion of interferon (IFN)-?
Positive_regulation (induces) of Positive_regulation (Stimulation) of DCs
8) Confidence 0.13 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.11

General Comments

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