INT157834

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3) transmembrane transport (Slc9a3)
Anatomy Link Frequency
ascending limb 1
Slc9a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 9 10.00 Low Low
isoflurane 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.96 Very High Very High Very High
Chronic Renal Failure 248 99.20 Very High Very High Very High
Kidney Stones 16 95.80 Very High Very High Very High
Hypercalcemia 3 61.60 Quite High
Hematuria 1 60.48 Quite High
Hypertrophy 22 5.00 Very Low Very Low Very Low
Uremia 8 5.00 Very Low Very Low Very Low
Natriuresis 5 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Acute Renal Failure 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, mice lacking NHE3 showed decreased expression of BSC-1 and sodium wasting (33), however they also had decreased SNGFR in contrast to CRF (34).
Negative_regulation (lacking) of NHE3 associated with chronic renal failure
1) Confidence 0.33 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.43 Pain Relevance 0
The observed decrease in BSC-1 abundance in the NHE3 knockout mice is unexplained based on current knowledge regarding the regulation of these transporters and further investigation is needed to address this.



Negative_regulation (decrease) of NHE3 associated with targeted disruption
2) Confidence 0.33 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.43 Pain Relevance 0
We previously reported that the down-regulation of transient receptor potential vanilloid 5 (TRPV5), sodium-hydrogen exchanger 3 (NHE3), sodium-glucose cotransporter 1 (SGLT1), and sodium-potassium-chloride cotransporter type 2 (NKCC2) is associated with hypercalciuria and that thiazides decreased calcium excretion by 50% in hypercalciuric rats induced by high salt or high calcium diet (12).
Negative_regulation (regulation) of sodium-hydrogen exchanger 3 associated with kidney stones
3) Confidence 0.32 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.68 Pain Relevance 0
Thick ascending limb sodium transporters NHE3 and NKCC2 were downregulated in ISOM and NaPi2 was decreased in CTX/OSOM, whereas NCC and ENaC were not consistently downregulated.
Negative_regulation (downregulated) of NHE3 in ascending limb
4) Confidence 0.27 Published 2009 Journal Nephrol. Dial. Transplant. Section Body Doc Link 19193739 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox