INT157835

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.25
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a1) transmembrane transport (Slc12a1)
Anatomy Link Frequency
external 1
ascending limb 1
Slc12a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 16 97.04 Very High Very High Very High
lidocaine 4 90.56 High High
ischemia 18 81.64 Quite High
imagery 42 80.64 Quite High
depression 6 74.56 Quite High
anesthesia 14 71.84 Quite High
local anesthetic 1 56.48 Quite High
GABAergic 1 54.00 Quite High
Central nervous system 1 51.76 Quite High
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 189 99.64 Very High Very High Very High
Ketoacidosis 363 99.34 Very High Very High Very High
Kidney Stones 32 99.16 Very High Very High Very High
Hypoxia 12 90.32 High High
Brain Hemorrhage 27 85.24 High High
Cv Unclassified Under Development 18 81.64 Quite High
Volume Depletion And Dehydration 34 78.72 Quite High
Respiratory Failure 6 75.52 Quite High
Middle Cerebral Artery Infarction 9 68.96 Quite High
Hypercalcemia 2 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that the down-regulation of transient receptor potential vanilloid 5 (TRPV5), sodium-hydrogen exchanger 3 (NHE3), sodium-glucose cotransporter 1 (SGLT1), and sodium-potassium-chloride cotransporter type 2 (NKCC2) is associated with hypercalciuria and that thiazides decreased calcium excretion by 50% in hypercalciuric rats induced by high salt or high calcium diet (12).
Negative_regulation (regulation) of NKCC2 associated with kidney stones
1) Confidence 0.37 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.71 Pain Relevance 0
We previously reported that the down-regulation of transient receptor potential vanilloid 5 (TRPV5), sodium-hydrogen exchanger 3 (NHE3), sodium-glucose cotransporter 1 (SGLT1), and sodium-potassium-chloride cotransporter type 2 (NKCC2) is associated with hypercalciuria and that thiazides decreased calcium excretion by 50% in hypercalciuric rats induced by high salt or high calcium diet (12).
Negative_regulation (regulation) of sodium-potassium-chloride cotransporter type 2 associated with kidney stones
2) Confidence 0.37 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.71 Pain Relevance 0
Thick ascending limb sodium transporters NHE3 and NKCC2 were downregulated in ISOM and NaPi2 was decreased in CTX/OSOM, whereas NCC and ENaC were not consistently downregulated.
Negative_regulation (downregulated) of NKCC2 in ascending limb
3) Confidence 0.35 Published 2009 Journal Nephrol. Dial. Transplant. Section Body Doc Link 19193739 Disease Relevance 0 Pain Relevance 0
Neither bumetanide, a specific inhibitor of NKCC, nor Na(+)-free external solution had any effect on the LC-HCl-induced E(GABA) shift.
Negative_regulation (inhibitor) of NKCC in external associated with gaba
4) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20580693 Disease Relevance 0.06 Pain Relevance 1.00
We investigated CBF and edema formation in a rat model of DKA and determined the effects of bumetanide, an inhibitor of Na-K-Cl cotransport.
Negative_regulation (inhibitor) of Na-K-Cl associated with pressure and volume under development and ketoacidosis
5) Confidence 0.05 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551666 Disease Relevance 1.20 Pain Relevance 0.08
The present finding that bumetanide increases cerebral ADC values in the DKA rats is consistent with the hypothesis that in DKA, cell swelling is diminished by inhibition of Na-K-Cl cotransport.
Negative_regulation (inhibition) of Na-K-Cl associated with pressure and volume under development and ketoacidosis
6) Confidence 0.05 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 1.58 Pain Relevance 0.18
CONCLUSIONS— These data demonstrate that CE in DKA is accompanied by cerebral hypoperfusion before treatment and suggest that blocking Na-K-Cl cotransport may reduce cerebral cell swelling.



Negative_regulation (blocking) of Na-K-Cl associated with pressure and volume under development and ketoacidosis
7) Confidence 0.05 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551666 Disease Relevance 1.00 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox