INT157836

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 8.37
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2)
transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)
Anatomy Link Frequency
kidney 6
plasma 2
duct 2
urine 2
Aqp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 7 97.64 Very High Very High Very High
medulla 7 94.20 High High
antagonist 33 92.32 High High
ischemia 11 50.00 Quite Low
isoflurane 28 32.40 Quite Low
anesthesia 23 25.00 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
withdrawal 9 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 907 100.00 Very High Very High Very High
Diabetes Insipidus 9 97.60 Very High Very High Very High
Polyuria 11 95.64 Very High Very High Very High
Renal Disease 33 91.12 High High
Uremia 28 84.12 Quite High
Water Intoxication 3 83.52 Quite High
Natriuresis 20 81.88 Quite High
Sepsis 2 79.56 Quite High
Acute Renal Failure 7 79.16 Quite High
Hypertrophy 77 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreased AQP2 expression in CRF rats was not altered in response to candesartan treatment; 3) Candesartan treatment was associated with decreased NHE3 and TSC expression in CRF, which could be due to the Ang II AT1 receptor blockade and/or decreased aldosterone levels; and 4) BSC-1 expression was increased in both CRF groups and the increased expression of BSC-1 was more prominent in candesartan-treated CRF rats compared with vehicle-treated CRF rats.
Neg (not) Regulation (altered) of Gene_expression (expression) of AQP2 associated with chronic renal failure
1) Confidence 0.57 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.24 Pain Relevance 0
In the present study, we further examine whether Ang II AT1 receptor blocker candesartan treatment in rats with CRF, where plasma vasopressin and AngII levels are elevated, could alter the downregulation of renal AQP2 expression and decreased urine concentration which were already seen in CRF rats (7).
Regulation (alter) of Gene_expression (expression) of AQP2 in urine associated with chronic renal failure
2) Confidence 0.57 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.73 Pain Relevance 0.04
The long-term regulation is due to a change in AQP-2 mRNA expression followed by AQP2 synthesis [2].
Regulation (change) of Gene_expression (expression) of AQP-2 mRNA
3) Confidence 0.44 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.28 Pain Relevance 0
Interestingly, however, taurine supplementation does not significantly affect plasma AVP, urine osmolality [18] or renal aquaporin2 expression.
Neg (not) Regulation (affect) of Gene_expression (expression) of aquaporin2 in plasma
4) Confidence 0.43 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994366 Disease Relevance 0.06 Pain Relevance 0
Thus, these studies all provide firm evidence for the decreased of vasopressin-regulated water channel AQP2 expression and the significant defects in the collecting duct of the kidneys from CRF.
Regulation (regulated) of Gene_expression (expression) of AQP2 in duct associated with chronic renal failure
5) Confidence 0.42 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.80 Pain Relevance 0.05
In the present study, we aimed to examine the effects of AngII AT1 receptor blockade on the expression of major renal sodium transporters (NHE3, BSC-1, and TSC) and vasopressin-regulated aquaporin-2 (AQP2) in rats with an early stage of CRF induced by 5/6 nephrectomy.
Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of aquaporin-2 associated with chronic renal failure
6) Confidence 0.42 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.36 Pain Relevance 0.14
In contrast, the whole kidney AQP2 expression in CRF rats was not altered in response to candesartan treatment (Fig. 3, Table 2).


Neg (not) Regulation (altered) of Gene_expression (expression) of AQP2 in kidney associated with chronic renal failure
7) Confidence 0.42 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.51 Pain Relevance 0
In the present study, we aimed to examine the effects of AngII AT1 receptor blockade on the expression of major renal sodium transporters (NHE3, BSC-1, and TSC) and vasopressin-regulated aquaporin-2 (AQP2) in rats with an early stage of CRF induced by 5/6 nephrectomy.
Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of AQP2 associated with chronic renal failure
8) Confidence 0.42 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.36 Pain Relevance 0.14
Our results suggest that the abnormal urine dilution capacity in chronic kidney disease stage III and IV is due to a lower ability of the principal cell in the distal part of the nephron to down regulate the expression of the AQP2 water channels and in that way promote water excretion.
Regulation (regulate) of Gene_expression (expression) of AQP2 in kidney associated with chronic renal failure
9) Confidence 0.39 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.32 Pain Relevance 0
Next, we aimed to examine the changes of iNOS expression and activated macrophage infiltration in the kidney and the effects of iNOS inhibition on AQP2 and NKCC2 expression in LPS rats.
Regulation (effects) of Gene_expression (expression) of AQP2 in kidney
10) Confidence 0.26 Published 2009 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 19193739 Disease Relevance 0.47 Pain Relevance 0
Angiotensin II AT1 Receptor Blockade Changes Expression of Renal Sodium Transporters in Rats with Chronic Renal Failure

We aimed to examine the effects of angiotensin II AT1 receptor blocker on the expression of major renal sodium transporters and aquaporin-2 (AQP2) in rats with chronic renal failure (CRF).

Spec (examine) Regulation (effects) of Gene_expression (expression) of aquaporin-2 associated with chronic renal failure
11) Confidence 0.25 Published 2005 Journal Journal of Korean Medical Science Section Title Doc Link PMC2808601 Disease Relevance 1.78 Pain Relevance 0
In addition, our results are in good accordance with animal experiments, which have demonstrated a vasopressin resistant down regulation in expression of AQP2, when urinary concentrating ability was impaired, i. e. in nephrogenic diabetes insipidus, post-obstructive polyuria, and renal failure [1-3,9].
Regulation (regulation) of Gene_expression (expression) of AQP2 associated with polyuria, chronic renal failure and diabetes insipidus
12) Confidence 0.20 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.46 Pain Relevance 0

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