INT157840

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.35
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Darc) signal transducer activity (Darc)
Anatomy Link Frequency
T-cell 2
Darc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 76 100.00 Very High Very High Very High
Arthritis 50 99.84 Very High Very High Very High
cytokine 55 99.80 Very High Very High Very High
Inflammation 51 96.52 Very High Very High Very High
antagonist 4 83.96 Quite High
Inflammatory response 13 76.64 Quite High
anesthesia 4 75.00 Quite High
ischemia 12 50.00 Quite Low
methotrexate 14 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 10 99.84 Very High Very High Very High
Plasmodium Infection 17 99.12 Very High Very High Very High
Infection 9 98.80 Very High Very High Very High
Juvenile Chronic Polyarthritis 40 97.84 Very High Very High Very High
INFLAMMATION 66 96.52 Very High Very High Very High
Fever 6 92.08 High High
Hypertension 2 91.68 High High
Injury 55 89.12 High High
Stress 6 78.16 Quite High
Disease 16 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
can be the mediator of the up-regulation of chemokines and cytokines during malaria infection, which is independent of TLRs but dependent on MyD88 [46].
Regulation (regulation) of chemokines associated with chemokine, plasmodium infection, infection and cytokine
1) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.86 Pain Relevance 0.30
Further, the study suggested differential regulation of the two chemokines, i.e., KC, and MIP-2, in hepatic IR response.
Regulation (regulation) of chemokines associated with chemokine
2) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.29 Pain Relevance 0.27
Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis.

Regulation (targets) of chemokines in T cells associated with chemokine, inflammation, juvenile chronic polyarthritis and arthritis
3) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526593 Disease Relevance 0.64 Pain Relevance 0.55
The operation significantly increased the chemokines monocyte chemoattractant protein (MCP)-1 and regulated upon activation, normal T-cell expressed, and secreted (RANTES) in rat serum, while enteral nutrition caused a further significant increase in chemokine levels in serum. mRNA chemokine expression in liver was increased in a similar pattern.
Regulation (regulated) of chemokines in T-cell associated with chemokine
4) Confidence 0.00 Published 2009 Journal Mol Nutr Food Res Section Abstract Doc Link 19194968 Disease Relevance 0.56 Pain Relevance 0.35

General Comments

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