INT157849

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.72
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (FKBP5) protein folding (FKBP5) nucleolus (FKBP5)
nucleus (FKBP5) cytoplasm (FKBP5)
Anatomy Link Frequency
brain structure 1
frontal cortex 1
FKBP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 4 98.30 Very High Very High Very High
depression 8 97.12 Very High Very High Very High
fluoxetine 2 94.24 High High
antidepressant 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 99.68 Very High Very High Very High
Depression 8 97.12 Very High Very High Very High
Stress 8 93.04 High High
Attention Deficit Hyperactivity Disorder 2 88.04 High High
Anxiety Disorder 2 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that the increase in hippocampal GR level and low concentration of FKBP51 in the frontal cortex may be responsible for enhanced glucocorticoid action in depression.
Negative_regulation (concentration) of FKBP51 in frontal cortex associated with depression and urological neuroanatomy
1) Confidence 0.32 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19195790 Disease Relevance 0.86 Pain Relevance 0.33
Western blot study revealed that GR level was significantly elevated in the hippocampus but not in the frontal cortex of prenatally stressed rats, whereas concentration of FKBP51 was decreased only in the former brain structure.
Negative_regulation (decreased) of FKBP51 in brain structure associated with urological neuroanatomy and hippocampus
2) Confidence 0.32 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19195790 Disease Relevance 0.86 Pain Relevance 0.36

General Comments

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