INT157849

Context Info Confidence 0.32 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.72 Pain Relevance 0.69

isomerase activity (FKBP5) protein folding (FKBP5) nucleolus (FKBP5) nucleus (FKBP5) cytoplasm (FKBP5)

Anatomy Link Frequency brain structure 1 frontal cortex 1 FKBP5 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 4 98.30 depression 8 97.12 fluoxetine 2 94.24 antidepressant 2 75.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 6 99.68 Depression 8 97.12 Stress 8 93.04 Attention Deficit Hyperactivity Disorder 2 88.04 Anxiety Disorder 2 86.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data indicate that the increase in hippocampal GR level and low concentration of FKBP51 in the frontal cortex may be responsible for enhanced glucocorticoid action in depression.

Negative_regulation (concentration) of FKBP51 in frontal cortex associated with depression and urological neuroanatomy

1) Confidence 0.32 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19195790 Disease Relevance 0.86 Pain Relevance 0.33

Western blot study revealed that GR level was significantly elevated in the hippocampus but not in the frontal cortex of prenatally stressed rats, whereas concentration of FKBP51 was decreased only in the former brain structure.

Negative_regulation (decreased) of FKBP51 in brain structure associated with urological neuroanatomy and hippocampus

2) Confidence 0.32 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19195790 Disease Relevance 0.86 Pain Relevance 0.36

General Comments

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