INT157852

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.10
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) aging (Sod2)
mitochondrion organization (Sod2) DNA binding (Sod2) response to stress (Sod2)
Anatomy Link Frequency
thyroid 1
spinal cord 1
Sod2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 6 100.00 Very High Very High Very High
anesthesia 2 99.20 Very High Very High Very High
ischemia 6 96.80 Very High Very High Very High
Spinal cord 9 96.44 Very High Very High Very High
tolerance 1 78.04 Quite High
Neurobehavioral 1 59.84 Quite High
Kinase C 3 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 12 99.58 Very High Very High Very High
Infection 4 98.44 Very High Very High Very High
Death 1 98.04 Very High Very High Very High
Spinal Cord Ischemia 6 96.80 Very High Very High Very High
Pressure Volume 2 Under Development 1 95.52 Very High Very High Very High
Apoptosis 6 82.00 Quite High
Hepatotoxicity 7 75.00 Quite High
Neurodegenerative Disease 1 57.04 Quite High
Toxicity 11 50.00 Quite Low
Reperfusion Injury 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, protein carbonyl and lipid peroxidation, also known to be induced by oxidative stress, were significantly increased in SOD2 knockdown rats.
Positive_regulation (increased) of SOD2 associated with stress
1) Confidence 0.50 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.53 Pain Relevance 0.26
Serum AST and ALT were significantly increased by single oral administration of acetaminophen (1000 mg/kg) to these SOD2-knockdown rats without fasting compared with the control adenovirus infected groups.
Positive_regulation (increased) of SOD2-knockdown associated with paracetamol
2) Confidence 0.50 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.57 Pain Relevance 0.26
HBO-PC enhanced activities of Mn-superoxide dismutase (Mn-SOD) and catalase, as well as the expression of Bcl-2 in the mitochondria in the normal spinal cord at 24 h after the last pretreatment (before spinal cord ischemia), and retained higher levels throughout the early reperfusion in the ischemic spinal cord.
Positive_regulation (enhanced) of Mn-superoxide dismutase in spinal cord associated with ischemia and spinal cord
3) Confidence 0.28 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19196076 Disease Relevance 0.77 Pain Relevance 0.66
Other antioxidant gene transcripts were induced in the rat thyroid after NaI exposure, including Gpx1 and Gpx2 (1.4- and 2.4-fold, respectively), Sod2 (1.6 fold), Txnrd1 (1.5-fold), heme oxygenase (Hmox1, 1.9-fold), and NAD(P)H dehydrogenase quinone (Nqo1, 2.2-fold; Table 5).
Positive_regulation (induced) of Sod2 in thyroid
4) Confidence 0.28 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.24 Pain Relevance 0

General Comments

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