INT15786

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.12
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (AHSP) protein folding (AHSP) cytoplasm (AHSP)
Anatomy Link Frequency
Endothelial cell 2
endothelium 2
vessels 1
plaque 1
parietal 1
AHSP (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 8 97.56 Very High Very High Very High
antagonist 5 84.88 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1 98.64 Very High Very High Very High
Hypertension 22 98.32 Very High Very High Very High
Cv General 3 Under Development 8 97.56 Very High Very High Very High
Spasticity 1 97.28 Very High Very High Very High
Hypoxia 10 96.84 Very High Very High Very High
Increased Venous Pressure Under Development 32 95.44 Very High Very High Very High
Adult Respiratory Distress Syndrome 5 94.64 High High
Atherosclerosis 7 94.60 High High
Disease 6 93.96 High High
Reperfusion Injury 1 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial cell damage and impairment of EDRF production may also contribute to acute and chronic pulmonary hypertension.
Gene_expression (production) of EDRF in Endothelial cell associated with hypertension
1) Confidence 0.78 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 1.12 Pain Relevance 0.12
EDRF is a potent, endogenous vasodilator that is produced and released from endothelial cells and subsequently causes the relaxation of VSM through the activation of soluble guanylate cyclase and an increase in VSM cyclic GMP.
Gene_expression (produced) of EDRF in endothelial cells
2) Confidence 0.78 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0 Pain Relevance 0
EDRF is present in all vascular beds, large and small vessels, and in a wide range of species.
Gene_expression (present) of EDRF in vessels
3) Confidence 0.78 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0.48 Pain Relevance 0
It is associated with decreased production of EDRF/NO, which probably contributes significantly to the aggravation of endothelial and parietal lesions and to the natural progression of atherosclerotic disease in general.
Gene_expression (production) of EDRF in parietal associated with atherosclerosis and disease
4) Confidence 0.75 Published 1993 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 8010861 Disease Relevance 0.77 Pain Relevance 0.10
Initial studies have shown that the endothelium may play a role in mediating the vascular actions of anesthetics, and that anesthetics can inhibit the production, release, or action of EDRF.
Gene_expression (production) of EDRF in endothelium
5) Confidence 0.67 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0.99 Pain Relevance 0.11
These results suggest that at least two or more receptor-coupled system may be involved in generation of EDRF.
Gene_expression (generation) of EDRF
6) Confidence 0.60 Published 1997 Journal Orv Hetil Section Abstract Doc Link 9340578 Disease Relevance 0.92 Pain Relevance 0.07
For lipid lowering drugs, the exact mechanism of action is still not clear; the results of quantitated coronary angiography (QCA) revealing a small but significant increase in luminal size in stenotic areas can be explained both by stabilization of endothelial function (increased EDRF production)--as demonstrated in animal studies--leading to a decrease in basal tone, and by a decrease in plaque volume (so far not evidenced by QCA in man).
Gene_expression (production) of EDRF in plaque
7) Confidence 0.58 Published 1991 Journal Schweiz Med Wochenschr Section Abstract Doc Link 1763301 Disease Relevance 0.32 Pain Relevance 0
The potential interactions of anesthetics with EDRF production and action in cell types other than the endothelium have not yet been explored.
Gene_expression (production) of EDRF in endothelium
8) Confidence 0.53 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0.52 Pain Relevance 0

General Comments

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