INT1579
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Men with PRL-producing macroadenomas often present with hypogonadism and impotence. | |||||||||||||||
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The aim of the present study was to assess levels of BB PRL, B PRL, little PRL (L PRL) and G PRL in hyperprolactinemic patients with no menstrual alterations or galactorrhea. | |||||||||||||||
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The aim of the present study was to assess levels of BB PRL, B PRL, little PRL (L PRL) and G PRL in hyperprolactinemic patients with no menstrual alterations or galactorrhea. | |||||||||||||||
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We present a unique case of a prolactin (PRL)-producing pituitary adenoma showing incomplete neuronal differentiation without ganglion cells. | |||||||||||||||
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We present a unique case of a prolactin (PRL)-producing pituitary adenoma showing incomplete neuronal differentiation without ganglion cells. | |||||||||||||||
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Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor. | |||||||||||||||
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Our case is the first PRL-producing pituitary adenoma showing incomplete neuronal differentiation lacking mature ganglion cells. | |||||||||||||||
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Because glycosylation is a posttranslational step in the processing of PRL, our studies suggest that the acute release of PRL in response to physiological and pharmacological secretagogues may reflect the output of more recently synthesized PRL from the pituitary. | |||||||||||||||
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Most of the above mentioned medications lead to an increase in prolactin plasma concentration through an influence on prolactin secretion control, primarily removing inhibitor pathways or directly stimulating prolactin production by the lactotroph cells. | |||||||||||||||
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The dopamine-mediated inhibition of prolactin secretion occurs through the binding of D2 receptors on the membrane of lactotroph cells and involves several signal transduction systems, resulting in inhibition of prolactin gene transcription, reduction of prolactin synthesis and release. | |||||||||||||||
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Histamine-induced prolactin production is mediated by dopaminergic as well as serotoninergic neurons, but other PRFs (eg, beta-endorphin, VIP, vasopressin or TRH) may be involved (Knigge 1990). | |||||||||||||||
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TRH physiologic role is unresolved, but it is thought to stimulate both prolactin gene expression (via protein kinase C pathway) and prolactin release from anterior pituitary. | |||||||||||||||
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However, Schlienger et al showed that basal plasma levels of prolactin and delta prolactin response to TRH were increased in women on clomipramine but remained normal under maprotiline, in agreement with the different pharmacologic effect of these two classes of drugs, tricyclics mainly inhibiting serotonin, while tetracyclics rather norepinephrine recaptation (Schlienger et al 1980). | |||||||||||||||
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Prolactin is produced in vitro by decidualized human endometrium and is secreted in vivo into the uterine luminal fluid of cynomolgus monkeys. | |||||||||||||||
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Uterine luminal fluid prolactin was detectable in all samples. | |||||||||||||||
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This study establishes that (1) frequent uterine luminal fluid sampling is possible; (2) uterine luminal fluid volume decreases in the luteal phase; (3) uterine luminal fluid prolactin is detectable in vivo in women and its concentration increases in the luteal phase; and (4) cyclic human uterine luminal fluid prolactin levels differ from those in cynomolgus monkeys and from those anticipated from human in vitro studies. | |||||||||||||||
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High-PRL sera and purified human PRL produced prompt increases in the frequency and the amplitude of the spontaneous contractions of the rat uterus. | |||||||||||||||
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Gjonnaess in his study of long term follow up showed no difference between baseline PRL levels and PRL levels after 3 months or later after LOD [30]. | |||||||||||||||
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Eldib et al in their unpublished study on 20 women with PCOS showed that LOD was associated with increased PRL levels by 7 folds two weeks after operation. | |||||||||||||||
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Hyperprolactinemia also has been found in the patients with active systemic lupus erythematosus, because prolactin can be produced from human activated lymphocytes. | |||||||||||||||
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